Diphtheria in Metro Manila, the Philippines 2006–2017: A Clinical, Molecular, and Spatial Characterization
| Autor: | Alexis Q. Dimapilis, Chris Smith, Elizabeth Freda O. Telan, Nobuo Saito, Fumihito Nakayama, Ferdinand De Guzman, Christopher M. Parry, Dorcas Valencia Umipig, Motoi Suzuki, Eumelia P. Salva, Rontgene M. Solante, Kohei Toda, Virginia O Dimapilis, Koya Ariyoshi, Hiroshi Fujii |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
wc_320 medicine.medical_specialty Pediatrics wa_950 Philippines 030231 tropical medicine wa_395 03 medical and health sciences 0302 clinical medicine Epidemiology Case fatality rate medicine Global health Humans 030212 general & internal medicine Child Articles and Commentaries Retrospective Studies Corynebacterium diphtheriae biology business.industry Diphtheria diphtheria antitoxin the Philippines vaccination medicine.disease biology.organism_classification Vaccination AcademicSubjects/MED00290 Infectious Diseases Infectious disease (medical specialty) Child Preschool Multilocus sequence typing business MLST Multilocus Sequence Typing |
| Zdroj: | CLINICAL INFECTIOUS DISEASES Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America |
| ISSN: | 1058-4838 |
| Popis: | Background Diphtheria is a vaccine-preventable disease that persists as a global health problem. An understanding of the pattern of disease is lacking in low- and middle-income countries such as the Philippines. Methods We conducted a retrospective review of the clinical, microbiological, and epidemiological features of patients admitted with a clinical diagnosis of diphtheria to an infectious disease referral hospital in Metro Manila, the Philippines, between 2006 and 2017. Cases were mapped and the distribution was compared with population density. Corynebacterium diphtheriae isolates from between 2015 and 2017 were examined by multilocus sequence typing (MLST). Results We studied 267 patients (range:12−54 cases/year) admitted between 2006 and 2017. The case fatality rate (CFR) was 43.8% (95% confidence interval, 37.8−50.0%). A higher number of cases and CFR was observed among children We studied 267 patients with diphtheria hospitalized in Metro Manila over 11 years. Case fatality rate was 43.8%, higher in children |
| Databáze: | OpenAIRE |
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