Cell proliferation, cell death and angiogenesis in early and advanced gastric cancer of intestinal type
| Autor: | Marcella Gallorini, Piero Tosi, Maria I. Filipe, R Vatti, Carla Vindigni, Alfonso De Stefano, Franco Roviello, L Presenti, Clelia Miracco, Donatella Spina, Enrico Pinto |
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| Rok vydání: | 1997 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty Mitotic index Angiogenesis TNM staging Biology Azure Stains Neovascularization angiogenesis histotype Stomach Neoplasms medicine Carcinoma Humans Neoplasm Invasiveness Neoplasm Staging Cell Death Neovascularization Pathologic Staining and Labeling Cell growth gastric cancer Stomach Cell Cycle Reproducibility of Results Cancer DNA Neoplasm medicine.disease Intestines medicine.anatomical_structure Oncology Apoptosis Lymphatic Metastasis Cancer research Tumor Suppressor Protein p53 medicine.symptom cell death Cell Division |
| Zdroj: | International Journal of Cancer. 74:637-641 |
| ISSN: | 1097-0215 0020-7136 |
| DOI: | 10.1002/(sici)1097-0215(19971219)74:6<637::aid-ijc14>3.0.co;2-2 |
| Popis: | Mitotic (MI) and apoptotic index (AI), the sum of the 2, i.e., the turnover index (TI), tumor neovascularization (NV) and p53 expression, as well as tumor grading and node status, are evaluated in early and advanced gastric-cancer cases. T1 cases show significantly less frequent lymph-node invasion and lower tumor grade, and, taken together, have significantly lower MI, AI and TI and higher values of NV than the T2‐3 cases. However, correlation of the variables shows that the above-mentioned discrimination is due to a minority of T1 cases (11 out of 33), while the majority of them are allocated in the same 95% ellipse of tolerance of the T2‐3 cases. Int. J. Cancer 74:637‐641, 1997. r 1997 Wiley-Liss, Inc. Limited or extensive neoplastic infiltration of the gastric wall characterizes early or advanced cancer of the stomach. The prevalence in the same age (Johansen, 1976) seems to indicate that early and advanced gastric cancer might be an expression of different tumors with diverse biological potential, notwithstanding identical histotypes, race and gender. Among the parameters that can be used to test such potential, cell proliferation, cell death (apoptosis) and genes such as p53 may be of importance, as well as tumor vascularization. Although tumor-cell proliferation and p53 expression have been extensively studied in gastric cancer, there are few studies dealing with tumor-cell death. Furthermore, few have addressed the critical issues of cell proliferation and death (Maeda et al., 1995; Shinohara et al., 1996), and of angiogenesis (Maeda et al., 1995) independent of standard histopathological grading and staging in gastric cancer. In the present investigation, we studied 89 cases of gastric cancer, in order to find differences, if any, in tumor cell kinetics, angiogenesis and p53 expression between tumors in different stage of growth. |
| Databáze: | OpenAIRE |
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