The potential role of T2*-weighted multi-echo data image combination as an imaging marker for intraplaque hemorrhage in carotid plaque imaging
| Autor: | Johan Wassélius, Jonas Svensson, Claes Håkansson, Karin Markenroth Bloch, Roger Siemund, Makda HaileMichael, My Truong, Isabel Gonçalves, Jimmy Lätt |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Hemorrhage Hemosiderin Intraplaque hemorrhage Methemoglobin Vessel wall imaging Medical technology Medicine Humans Radiology Nuclear Medicine and imaging R855-855.5 Stroke Aged Aged 80 and over business.industry Research Middle Aged medicine.disease Atherosclerosis Signal on Magnetic Resonance Imaging Carotid plaque Plaque Atherosclerotic Carotid Arteries Ischemic Attack Transient Plaque imaging Feasibility Studies Female T2 weighted Nuclear medicine business Hemoglobin degradation Multi echo MRI |
| Zdroj: | BMC Medical Imaging, Vol 21, Iss 1, Pp 1-7 (2021) BMC Medical Imaging |
| ISSN: | 1471-2342 |
| Popis: | Background Carotid atherosclerotic plaques with intraplaque hemorrhage (IPH) are associated with elevated stroke risk. IPH is predominantly imaged based on paramagnetic properties of the upstream hemoglobin degradation product methemoglobin. This is an explorative observational study to test the feasibility of a spoiled gradient echo based T2* weighted MRI sequence (3D MEDIC) for carotid plaque imaging, and to compare signs suggestive of the downstream degradation product hemosiderin on 3D MEDIC with signs of methemoglobin on a T1wBB sequence. Methods Patients with recent TIA or stroke were selected based on the presence on non-calcified plaque components on CTA to promote an enriched prevalence of IPH in the material. Patients (n = 42) underwent 3T MRI with 3D MEDIC and 2D turbo spin echo T1w black blood (T1wBB). Images were independently evaluated by two neuroradiologists and Cohens Kappa was used for inter-reader agreement for each sequence. Results The technical feasibility for 3D MEDIC, was 34/42 patients (81%). Non-calcified plaque components with susceptibility effect without simultaneous T1-shortening—a combination suggestive of hemosiderin, was seen in 13/34 of the plaques. An equally large group display elevated T1w signal in combination with signal loss on 3D MEDIC, a combination suggestive of both hemosiderin and methemoglobin. Cohen’s kappa for inter-reader agreement was 0.64 (CI 0.345–0.925) for 3D MEDIC and 0.94 (CI 0.81–1.00) for T1wBB. Conclusions 3D MEDIC shows signal loss, without elevated T1w signal on T1wBB, in non-calcified tissue in many plaques in this group of patients. If further studies, including histological verification, confirm that the 3D MEDIC susceptibility effect is indeed caused by hemosiderin, 3D MEDIC could aid in the detection of IPH, beyond elevation of T1w signal. |
| Databáze: | OpenAIRE |
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