The Gabriel-Colman rearrangement in biological systems: design, synthesis and biological evaluation of phthalimide and saccharin derivatives as potential mechanism-based inhibitors of human leukocyte elastase, cathepsin G and proteinase 3

Autor:	Lee S. Chong, Jeffrey B. Epp, Nadene Houser-Archield, Rongze Kuang, Radhika Venkataraman, John R. Hoidal, William C. Groutas
Rok vydání:	1995
Předmět:	Cathepsin G Magnetic Resonance Spectroscopy Stereochemistry Myeloblastin Clinical Biochemistry Pharmaceutical Science Phthalimides Biochemistry Phthalimide Structure-Activity Relationship chemistry.chemical_compound Saccharin Proteinase 3 Cathepsin L1 Drug Discovery Humans Structure–activity relationship Molecular Biology Pancreatic elastase Cathepsin Pancreatic Elastase Serine Endopeptidases Organic Chemistry Cathepsins Gabriel–Colman rearrangement humanities chemistry Molecular Medicine Leukocyte Elastase psychological phenomena and processes
Zdroj:	Bioorganic & Medicinal Chemistry. 3:187-193
ISSN:	0968-0896
DOI:	10.1016/0968-0896(95)00013-7
Popis:	The results of a structure-activity relationship study focusing on the interaction of a series of phthalimide and saccharin derivatives with leukocyte elastase, cathepsin G and proteinase 3 are described. The phthalimide derivatives were found to be inactive while some of the saccharin derivatives were found to be fair inhibitors of these enzymes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3d6ca74b45d99b8c6adb12b77db0c41 https://doi.org/10.1016/0968-0896(95)00013-7 Zobrazit plný text záznamu Full Text from ScienceDirect