Molecular wipes: application to epidemic keratoconjuctivitis
| Autor: | Marko Marttila, Niklas Arnberg, Olov Sterner, Ulf Ellervik, Sophie Manner, Karolina Aplander |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Keratoconjunctivitis Severe disease macromolecular substances Antiviral Agents Keratitis Adenoviridae Polyethylene Glycols Adenovirus Infections Human Cornea Structure-Activity Relationship Edema Drug Discovery medicine Humans Epidemics Cells Cultured Chemistry Virion Epithelial Cells medicine.disease Dermatology Virology Epidemic Keratoconjunctivitis Alkynes Liposomes Sialic Acids Molecular Medicine medicine.symptom |
| Zdroj: | Journal of medicinal chemistry. 54(19) |
| ISSN: | 1520-4804 |
| Popis: | Epidemic keratoconjunctivitis (EKC) is a severe disease of the eye, caused by members of the Adenoviridae (Ad) family, with symptoms such as keratitis, conjunctivitis, pain, edema, and reduced vision that may last for months or years. There are no vaccines or antiviral drugs available to prevent or treat EKC. It was found previously that EKC-causing Ads use sialic acid as a cellular receptor and demonstrated that soluble, sialic acid-containing molecules can prevent infection. In this study, multivalent sialic acid constructs based on 10,12-pentacosadiynoic acid (PDA) have been synthesized, and these constructs are shown to be efficient inhibitors of Ad binding (IC(50) = 0.9 μM) and Ad infectivity (IC(50) = 0.7 μM). The mechanism of action is to aggregate virus particles and thereby prevent them from binding to ocular cells. Such formulations may be used for topical treatment of adenovirus-caused EKC. |
| Databáze: | OpenAIRE |
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