Impact of Intragastric Balloon Treatment on Adipokines, Cytokines, and Metabolic Profile in Obese Individuals
| Autor: | Ricardo J. Fittipaldi-Fernandez, Cristina F. Diestel, Márcia Regina Simas Torres Klein, Marcella R. Guedes |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Adipokine Adipose tissue 030209 endocrinology & metabolism Body Mass Index 03 medical and health sciences Young Adult 0302 clinical medicine Insulin resistance Adipokines Internal medicine Weight Loss Medicine Humans Obesity Prospective Studies Intubation Gastrointestinal Device Removal Gastric Balloon Nutrition and Dietetics medicine.diagnostic_test Adiponectin business.industry Insulin Leptin Middle Aged medicine.disease Endocrinology Metabolome Cytokines 030211 gastroenterology & hepatology Surgery Resistin Female business Lipid profile hormones hormone substitutes and hormone antagonists |
| Zdroj: | Obesity surgery. 29(8) |
| ISSN: | 1708-0428 |
| Popis: | Obesity is accompanied by adipose tissue remodeling characterized by increased production of tumor necrosis factor-alpha (TNF-α), interleukin (IL)-6, leptin and resistin and reduced secretion of adiponectin, which favors inflammation, metabolic disorders, and cardiovascular diseases. Although intragastric balloon (IGB) can be considered safe and effective for weight loss, its effect on serum levels of these biomarkers has been evaluated only in a few studies, while no previous study evaluated its effect on circulating levels of resistin, TNF-α, and IL-6. The aim of this study was to evaluate the changes in serum levels of metabolic and inflammatory biomarkers in obese patients submitted to IGB treatment. A prospective observational study involving 42 patients with obesity using IGB for 6 months. The patients were evaluated, on the day of insertion and withdrawal or adjustment of IGB, for the following: anthropometric measures and serum levels of adiponectin, leptin, resistin, TNF-α, IL-6, high-sensitivity C-reactive protein (hs-CRP), glucose, insulin, uric acid, triglycerides, and total cholesterol and fractions. The body mass index decreased from 35.15 ± 0.41 to 29.50 ± 0.54 kg/m2. There was a reduction (p |
| Databáze: | OpenAIRE |
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