Whole body MR in patients with multiple myeloma
| Autor: | Alina Piekarek, Adam Nowicki, Piotr Sosnowski, Mieczysław Komarnicki |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Cancer Research
business.industry Salmon-Durie Plus (S-D Plus) Cancer medicine.disease Trunk Sagittal plane medicine.anatomical_structure Oncology Radiology Nuclear Medicine and imaging Coronal plane medicine Radiology Nuclear Medicine and imaging In patient Bone marrow whole-body MR (WB MR) multiple myeloma (MM) Stage (cooking) Nuclear medicine business Multiple myeloma |
| Zdroj: | Reports of Practical Oncology & Radiotherapy. (3):80-84 |
| ISSN: | 1507-1367 |
| DOI: | 10.1016/S1507-1367(10)60098-3 |
| Popis: | Background Multiple myeloma is a cancer of plasma cells which leads to bone marrow infiltration. Aim Whole-body MR is the most sensitive imaging method available to detect multiple myeloma lesions. Material and Methods MR scans were performed in 100 patients with multiple myeloma who were receiving treatment in the Haematology Clinic in Poznan in the years 2005–2006. Whole-body MR scans were performed with general coil 1.0 T in STIR sequences and T1 sequences, in coronal and sagittal planes with scanning area covering the head, neck, trunk and the limbs (FOV for specific regions was 36–48 cm). The bone lesions were classified as focal (monofocal/multifocal lesions), in-filtrative, mixed and “salt and pepper” type. Depending on the size of the lesions the patients were included in one of three groups according to Salmon-Durie Plus classification. Results Four main types of multiple myeloma were distinguished based on MR scans: focal (48 patients; monofocal in 10 patients), infiltrative (17 patients), mixed type (19 patients) and “salt and pepper” type (4 patients). The remaining 12 patients had no multiple myeloma lesions in the bone marrow. Additionally, in 18% of patients a soft tissue mass could be observed. According to Salmon-Durie Plus categorisation 27 subjects were classified as having stage I, 16 patients stage and 57 patients stage III disease. In 12% of patients MR data changed the disease staging. Conclusions WB MR is a sensitive and effective diagnostic method with an important impact on staging and further treatment of multiple myeloma. |
| Databáze: | OpenAIRE |
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