Outcomes of small pediatric donor kidney transplants according to donor weight
| Autor: | Marcelo Santos Sampaio, Hans Albin Gritsch, Suphamai Bunnapradist, Piyavadee Homkrailas, Erik L. Lum |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Transplantation medicine.medical_specialty Deceased donor Kidney Graft failure Pediatric donor business.industry Graft Survival Urology Single kidney Kidney Transplantation Tissue Donors medicine.anatomical_structure Primary outcome Risk Factors medicine Humans Graft survival business Child Proportional Hazards Models Retrospective Studies |
| Zdroj: | Transplant international : official journal of the European Society for Organ TransplantationReferences. 34(11) |
| ISSN: | 1432-2277 |
| Popis: | A small pediatric deceased donor (SPD) weight cutoff whether to transplant as en bloc (EB) or single pediatric (SP) kidney is uncertain. Using UNOS/OPTN data (2000-2019), 27 875 SPDs were divided by (i) EB (11.4%) or SP (88.6%) and (ii) donor weight [≤10 (5.4%),10-15 (8.3%),15-18 (3.7%),18-20 (2.9%), and20 kg (79.7%)]. SP20 kg and adult deceased donors (grouped by Kidney Donor Profile Index, KDPI,30, 30-85, and85) were used as references. The primary outcome was 10-year graft failure. In SP10 kg, the hazard ratio (HR) for overall graft failure was 1.64 (1.38-2.20) compared with EB10 kg, and 1.45 (1.18-1.80) compared with SP20 kg. In SP10-15 kg, HR was 1.31 (1.12-1.54) compared with EB10-15 kg, and 1.04 (0.91-1.18) compared with SP20 kg. In SP15 kg, the risk was the same as SP20 kg. Ten-year overall graft survival of SP 12 kg was comparable to SP20 kg (62% vs. 57%). Ten-year death censored graft failure of SP10-15 kg (70%) and SP15-18 kg (70%) was like the adult donors with KDPI 30-85 (67%). In conclusion, we recommend single kidney transplants from SPDs with weight12 kg to adult recipients in centers with experience in SPD transplants to optimize organ utilization. |
| Databáze: | OpenAIRE |
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