Enhancement of Learning and Memory by Elevating Brain Magnesium
| Autor: | Ming Gao Zhao, Guosong Liu, Arvind Govindarajan, Inna Slutsky, Xiang Zhao, Susumu Tonegawa, Bo I. Li, Ling Zhang, Min Zhuo, Chao Huang, Long Jun Wu, Nashat Abumaria |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Neuroscience(all) Presynaptic Terminals HUMDISEASE Neural facilitation Hippocampus Neurotransmission MOLNEURO Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Memory Memory improvement Animals Learning Magnesium 030304 developmental biology Brain Chemistry 0303 health sciences General Neuroscience Age Factors Brain Long-term potentiation Rats nervous system SIGNALING Synaptic plasticity NMDA receptor Memory consolidation Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Neuron. 65(2):165-177 |
| ISSN: | 0896-6273 |
| DOI: | 10.1016/j.neuron.2009.12.026 |
| Popis: | SUMMARY Learning and memory are fundamental brain functions affected by dietary and environmental factors. Here, we show that increasing brain magnesium using a newly developed magnesium compound (magnesium-L-threonate, MgT) leads to the enhancement of learning abilities, working memory, and short- and long-term memory in rats. The pattern completion ability was also improved in aged rats. MgT-treated rats had higher density of synaptophysin-/synaptobrevin-positive puncta in DG and CA1 subregions of hippocampus that were correlated with memory improvement. Functionally, magnesium increased the number of functional presynaptic release sites, while it reduced their release probability. The resultant synaptic reconfiguration enabled selective enhancement of synaptic transmission for burst inputs. Coupled with concurrent upregulation of NR2B-containing NMDA receptors and its downstream signaling, synaptic plasticity induced by correlated inputs was enhanced. Our findings suggest that an increase in brain magnesium enhances both short-term synaptic facilitation and long-term potentiation and improves learning and memory functions. |
| Databáze: | OpenAIRE |
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