Retinal microvascular abnormalities in patients after COVID-19 depending on disease severity
| Autor: | Gabriel Arcos, Anna Falcó, José García-Arumí, Susana Otero-Romero, Sandra Banderas García, Miguel A Zapata, Adrián Sánchez-Moltalvá, Daniel Velazquez-Villoria |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
medicine.medical_specialty retina Coronavirus disease 2019 (COVID-19) Adolescent Disease Asymptomatic Severity of Illness Index law.invention Serology 03 medical and health sciences chemistry.chemical_compound Cellular and Molecular Neuroscience Young Adult 0302 clinical medicine law Internal medicine medicine Humans macula Pandemics medicine.diagnostic_test business.industry SARS-CoV-2 COVID-19 imaging Retinal Middle Aged Clinical Science medicine.disease Intensive care unit Sensory Systems infection Pneumonia Ophthalmology chemistry Case-Control Studies Angiography 030221 ophthalmology & optometry medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | The British Journal of Ophthalmology British Journal of Ophthalmology |
| ISSN: | 1468-2079 0007-1161 |
| Popis: | BackgroundGlobal pandemic SARS-CoV-2 causes a prothrombotic state without fully elucidated effects. This study aims to analyse and quantify the possible retinal microvascular abnormalities.Materials and methodsCase–control study. Patients between 18 and 55 years old with PCR-confirmed SARS-CoV-2 infection within the last 3 months were included. Risk stratification: group 1—mild disease (asymptomatic/paucisymptomatic); group 2—moderate disease (required hospital admission with no acute respiratory distress) and group 3—severe disease (subjects who developed an acute respiratory distress were admitted in the intensive care unit and presented interleukin 6 values above 40 pg/mL). Age-matched volunteers with negative serology tests were enrolled to control group. A colour photograph, an optical coherence tomography (OCT) and an angiography using OCT centred on the fovea were performed.ResultsControl group included 27 subjects: group 1 included 24 patients, group 2 consisted of 24 patients and 21 participants were recruited for group 3. There were no funduscopic lesions, neither in the colour images nor in the structural OCT. Fovea-centred vascular density (VD) was reduced in group 2 and group 3 compared with group 1 and control group (control group vs group 2; 16.92 vs 13.37; p=0.009) (control group vs group 3; 16.92 vs .13.63; p=0.026) (group 1 vs group 2; 17.16 vs 13.37; p=0.006) (group 1 vs group 3; 17.16 vs 13.63 p=0.017).ConclusionPatients with moderate and severe SARS-CoV-2 pneumonia had decreased central retinal VD as compared with that of asymptomatic/paucisymptomatic cases or control subjects. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|