EFFECT OF PARTICLE SIZE ON SLOW PARTICLE CLEARANCE FROM THE BRONCHIAL TREE

Autor:	Michael Bailey, J. R. H. Smith, A. L. Shutt, M. J. Youngman, G. Etherington
Rok vydání:	2008
Předmět:	Adult Male Pulmonary and Respiratory Medicine Pathology medicine.medical_specialty Mucociliary clearance Clinical Biochemistry Analytical chemistry Bronchi Models Biological Administration Inhalation medicine Humans Particle Size Lung Molecular Biology Aerosols Gold Radioisotopes Chemistry Indium Radioisotopes Middle Aged medicine.anatomical_structure Deposition (aerosol physics) Mucociliary Clearance Polystyrenes Particle Female Gold Particle size Bolus (digestion) Respiratory tract Particle deposition
Zdroj:	Experimental Lung Research. 34:287-312
ISSN:	1521-0499 0190-2148
Popis:	The Human Respiratory Tract Model of the International Commission on Radiological Protection assumes that a fraction of particles deposited in the bronchial tree clears slowly, this fraction decreasing with increasing particle geometric diameter. To test this assumption, volunteers inhaled 5-microm aerodynamic diameter 111In-polystyrene and 198Au-gold particles simultaneously, as a 'bolus' at the end of each breath to minimize alveolar deposition. Because of the different densities (1.05 versus 19.3 g cm3), geometric diameters were about 5 and 1.2 microm, respectively, and corresponding predicted slowly cleared fractions were about 10% and 50%. However, lung retention of the 2 particles was similar in each subject. Retention at 24 hours, as a percentage of initial lung deposit (mean +/- SD) was 34 +/- 12 for polystyrene and 31 +/- 11 for the gold particles.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3d3605819ec6ec4850d52ea07822169 https://doi.org/10.1080/01902140802093196 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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