The Serotonin Transporter Polymorphism rs25531 Is Associated with Irritable Bowel Syndrome
| Autor: | Ruth Kohen, Monica Jarrett, Sang-Eun Jun, Kevin C. Cain, Sarah Symonds, Margaret M. Heitkemper, Grace P. Navaja |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Washington medicine.medical_specialty Candidate gene Physiology Single-nucleotide polymorphism Gastroenterology Polymorphism Single Nucleotide Risk Assessment Article Irritable Bowel Syndrome Gene Frequency Risk Factors Internal medicine medicine Odds Ratio Humans Genetic Predisposition to Disease Allele frequency Serotonin transporter Irritable bowel syndrome Serotonin Plasma Membrane Transport Proteins Chi-Square Distribution biology Case-control study Middle Aged medicine.disease Endocrinology Phenotype Gastrointestinal disorder Case-Control Studies biology.protein Female Serotonin |
| Popis: | Irritable bowel syndrome is a frequent gastrointestinal disorder of unknown etiology. The serotonin transporter regulates the intensity and duration of serotonin signaling in the gut and is, therefore, an attractive candidate gene for irritable bowel syndrome. Previous studies investigating the 5-HTTLPR and Stin2 VNTR polymorphisms of the serotonin transporter have proved inconclusive. In this exploratory study we therefore expanded the search for a possible association of the serotonin transporter with irritable bowel syndrome to include not only the 5-HTTLPR and Stin2 VNTR length polymorphisms, but also the functional single nucleotide polymorphism rs25531. We genotyped 186 patients with irritable bowel syndrome and 50 healthy control subjects raging in age from 18 to 70 years. Carriers of the rare G allele of rs25531 had approximately threefold increased odds of irritable bowel syndrome compared with healthy controls (OR 3.3, 95% CI 1.1-9.6). Our findings suggest that further investigation of the possible role of the serotonin transporter in the etiology of IBS is warranted. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|