Genome wide association studies (GWAS) and copy number variation (CNV) studies of the major psychoses: What have we learnt?
| Autor: | Puay San Woon, Kang Sim, Kok Wei Lee, Yik Ying Teo |
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| Rok vydání: | 2012 |
| Předmět: |
Ankyrins
Genetics Bipolar Disorder Calcium Channels L-Type DNA Copy Number Variations Cognitive Neuroscience Nerve Tissue Proteins Genomics Genome-wide association study Biology Genome PBRM1 Major Histocompatibility Complex Behavioral Neuroscience Neuropsychology and Physiological Psychology mental disorders Schizophrenia Humans Epistasis Genetic Predisposition to Disease Copy-number variation ANK3 Gene Transcription Factors |
| Zdroj: | Neuroscience & Biobehavioral Reviews. 36:556-571 |
| ISSN: | 0149-7634 |
| Popis: | Schizophrenia (SZ) and bipolar disorder (BPD) have high heritabilities and are clinically and genetically complex. Genome wide association studies (GWAS) and studies of copy number variations (CNV) in SZ and BPD have allowed probing of their underlying genetic risks. In this systematic review, we assess extant genetic signals from published GWAS and CNV studies of SZ and BPD up till March 2011. Risk genes associated with SZ at genome wide significance level (p value |
| Databáze: | OpenAIRE |
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