β2-adrenergic receptor control of endosomal PTH receptor signaling via Gβγ

Autor: Vanessa L. Wehbi, Jingming Chen, Masaki Noda, Juan M. Taboas, Kunhong Xiao, Jean-Pierre Vilardaga, Frederic Jean-Alphonse
Přispěvatelé: University of Pittsburgh School of Medicine, Pennsylvania Commonwealth System of Higher Education (PCSHE), Nanjing University (NJU)
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Cell signaling
G protein
Parathyroid hormone
Endosomes
Article
Receptors
G-Protein-Coupled
[SDV.BDLR.RS]Life Sciences [q-bio]/Reproductive Biology/Sexual reproduction
03 medical and health sciences
GTP-Binding Protein gamma Subunits
[SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB]
Humans
Receptor
Protein kinase A
Molecular Biology
Cells
Cultured
G protein-coupled receptor
Receptor
Parathyroid Hormone
Type 1
Chemistry
Parathyroid hormone receptor
GTP-Binding Protein beta Subunits
[SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry
Molecular Biology/Molecular biology
[SDV.BBM.MN]Life Sciences [q-bio]/Biochemistry
Molecular Biology/Molecular Networks [q-bio.MN]
Cell Biology
3. Good health
Cell biology
Protein Subunits
030104 developmental biology
HEK293 Cells
[SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology
Receptors
Adrenergic
beta-2
Signal transduction
Signal Transduction
Zdroj: Nature Chemical Biology
Nature Chemical Biology, Nature Publishing Group, 2017, 13 (3), pp.259-261. ⟨10.1038/nchembio.2267⟩
ISSN: 1552-4450
1552-4469
Popis: International audience; Cells express several G-protein-coupled receptors (GPCRs) at their surfaces, transmitting simultaneous extracellular hormonal and chemical signals into cells. A comprehensive understanding of mechanisms underlying the integrated signaling response induced by distinct GPCRs is thus required. Here we found that the b2-adrenergic receptor, which induces a short cAMP response, prolongs nuclear cAMP and protein kinase A (PKA) activation by promoting endosomal cAMP production in parathyroid hormone (PTH) receptor signaling through the stimulatory action of G protein G beta gamma subunits on adenylate cyclase type 2.
Databáze: OpenAIRE
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