Innate lymphoid cells
| Autor: | Mathilde J. H. Girard-Madoux, Adeline Crinier, Charlotte Viant, Eric Vivier |
|---|---|
| Přispěvatelé: | Centre d'Immunologie de Marseille - Luminy (CIML), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU) |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Innate immune system Effector Innate lymphoid cell General Medicine Biology General Biochemistry Genetics and Molecular Biology body regions 03 medical and health sciences 030104 developmental biology RAR-related orphan receptor gamma Immunity Immunology Cytotoxic T cell [SDV.IMM]Life Sciences [q-bio]/Immunology skin and connective tissue diseases Gene Transcription factor ComputingMilieux_MISCELLANEOUS |
| Zdroj: | médecine/sciences médecine/sciences, EDP Sciences, 2017, 33 (5), pp.534-542. ⟨10.1051/medsci/20173305018⟩ médecine/sciences, 2017, 33 (5), pp.534-542. ⟨10.1051/medsci/20173305018⟩ |
| ISSN: | 0767-0974 1958-5381 |
| DOI: | 10.1051/medsci/20173305018⟩ |
| Popis: | Innate Lymphoid Cells (ILC) are tissue-resident effector lymphocytes that differ from the B and T lymphocytes subsets since they lack specific antigen receptors derived from gene rearrangements. They can be divided into two groups, cytotoxic ILC (NK cells) which are dependent on the transcription factors Eomes and T-bet and produce IFN-γ, and helper-like ILC (ILC1, ILC2, ILC3) which are dependent on T-bet, GATA-3 or RORγT and produce IFN-γ, IL-5/IL-13 or IL-17/IL-22 respectively. Although they were described recently, ILC are the subject of a large number of studies that characterize their role as one of the first effectors of the innate immune response as well as in the development of a wide number of inflammatory disorders. |
| Databáze: | OpenAIRE |
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