Measurement of cardiovascular and pulmonary function endpoints and other physiological effects following partial or complete substitution of cigarettes with electronic cigarettes in adult smokers
| Autor: | Carl D. D’Ruiz, Grant O'Connell, X. Sherwin Yan, Donald W. Graff |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
medicine.medical_specialty Vital Capacity Blood Pressure Electronic Nicotine Delivery Systems 030204 cardiovascular system & hematology Toxicology Pulmonary function testing Nicotine 03 medical and health sciences FEV1/FVC ratio 0302 clinical medicine Heart Rate Internal medicine Heart rate medicine Humans 030212 general & internal medicine Adverse effect Lung Smoking Reduction business.industry Smoking Forced Expiratory Flow Rates Tobacco Products Tobacco Use Disorder General Medicine Respiratory Function Tests Cardiovascular physiology Blood pressure Anesthesia Cardiology Smoking Cessation business medicine.drug |
| Zdroj: | Regulatory Toxicology and Pharmacology. 87:36-53 |
| ISSN: | 0273-2300 |
| DOI: | 10.1016/j.yrtph.2017.05.002 |
| Popis: | Acute changes in select physiological parameters associated with cardiovascular physiology (systolic and diastolic blood pressure (BP) and heart rate (HR)), pulmonary function (FVC, FEV1, and exhaled CO and NO) and adverse events were measured in 105 clinically confined subjects who were randomized into groups that either completely or partially switched from conventional cigarettes to e-cigarettes or completely discontinued using tobacco and nicotine products altogether. Use of the e-cigarettes for five days under the various study conditions did not lead to higher BP or HR values, negative respiratory health outcomes or serious adverse health events. Reductions in BP and HR vital signs were observed in most of the participants that either ceased tobacco and nicotine products use altogether or switched completely to using e-cigarettes. Pulmonary function tests showed small but non-statistically significant improvements in FVC and FEV1 measurements in most use groups. Statistically significant (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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