Molecular markers and their prognostic impact in patients with advanced prostate cancer undergoing intermittent androgen suppression
| Autor: | G. Lunglmayr, Karl Pummer, H Augustin, L. Bayer, F. Tschurlovich, W. Kuber, C. Freibauer |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
Oncology Cancer Research medicine.medical_specialty medicine.drug_class Biopsy Urology Androgen suppression Tosyl Compounds Prostate cancer Prostate Internal medicine Antineoplastic Combined Chemotherapy Protocols Nitriles Biomarkers Tumor medicine Carcinoma Humans Anilides Testosterone Aged Cell Proliferation Neoplasm Staging Aged 80 and over medicine.diagnostic_test business.industry Goserelin Prostatic Neoplasms Androgen Antagonists Middle Aged Prognosis medicine.disease Androgen Gene Expression Regulation Neoplastic medicine.anatomical_structure Withholding Treatment business medicine.drug |
| Zdroj: | Prostate Cancer and Prostatic Diseases. 9:279-283 |
| ISSN: | 1476-5608 1365-7852 |
| DOI: | 10.1038/sj.pcan.4500883 |
| Popis: | Objective: Tumour features were evaluated during intermittent androgen suppression (IAS), and their prognostic impact on the first off-treatment time was analysed. Patients and methods: Twenty patients with advanced prostate cancer underwent three consecutive prostate biopsies during the first cycle, namely at the beginning of androgen deprivation, 8 months after continuous therapy and at the time of prostate-specific antigen (PSA) progression above 20 ng/ml. Biopsy specimens were immunohistochemically processed and analysed for the apoptotic index (AI), Ki-67, p53 and Bcl-2 to investigate eventual changes over time. Correlations and regression analysis were performed to assess the prognostic significance of clinical and pathological parameters in predicting the first off-treatment time. Results: In contrast to the AI, p53 and Bcl-2, Ki-67 was the only marker that significantly changed over time (P=0.008). The first off-treatment time correlated significantly with pretreatment PSA (r=−0.594; P |
| Databáze: | OpenAIRE |
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