Presepsin and Midregional Proadrenomedullin in Pediatric Oncologic Patients with Febrile Neutropenia
| Autor: | Marcello Ciaccio, Elisa Parisi, Giulia Bivona, Luisa Agnello, Anna Maria Ciaccio, Giuseppe Dejan Lucido, Ottavio Ziino, Alessandro Iacona, Rosaria Vincenza Giglio |
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| Přispěvatelé: | Ciaccio, Marcello, Ziino, Ottavio, Giglio, Rosaria Vincenza, Ciaccio, Anna Maria, Iacona, Alessandro, Lucido, Giuseppe Dejan, Parisi, Elisa, Bivona, Giulia, Agnello, Luisa |
| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment pediatric Clinical Biochemistry Lipopolysaccharide Receptors Neutropenia Adrenomedullin mr-proADM malignancie Neoplasms Internal medicine Antineoplastic Combined Chemotherapy Protocols Humans neutropenia Medicine Blood culture Protein Precursors Fever of unknown origin Child Febrile Neutropenia fever Chemotherapy medicine.diagnostic_test Receiver operating characteristic business.industry Presepsin Biochemistry (medical) Age Factors Prognosis medicine.disease Peptide Fragments ROC Curve oncologic Bacteremia Female business Biomarkers Febrile neutropenia |
| Zdroj: | Laboratory Medicine. 51:585-591 |
| ISSN: | 1943-7730 0007-5027 |
| Popis: | Objective In this study, we investigated the roles of presepsin (PSP) and midregional proadrenomedullin (mr-proADM) in children with febrile neutropenia (FN) due to chemotherapy. Methods We assessed 36 FN episodes in 26 children. Patients were classified into bacteremia (B) and fever of unknown origin (FUO) groups. We evaluated PSP and mr-proADM at admission (T0), after 24/48 h (T1), and after 5 days (T2). Results PSP and mr-proADM levels were elevated at T0 and significantly decreased at T2. mr-proADM levels did not significantly differ between the B and FUO groups. PSP levels significantly differed between the B and FUO groups only at T1. Both PSP and mr-proADM levels at T0 were a predictor of length of hospital stay but not of the duration of fever. Finally, receiver operating characteristic curve analysis showed that PSP and mr-proADM had low diagnostic accuracy for blood culture positivity. Conclusion PSP and mr-proADM display poor clinical usefulness for FN in oncologic children. |
| Databáze: | OpenAIRE |
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