RET proto-oncogene mutation in a mixed medullary-follicular thyroid carcinoma

Autor:	Fabio Orlandi, Sebastiano Filetti, Alessandro Mussa, Alberto Angeli, P. De Giuli, P. Caraci, Ilaria Gonzatto, Eusebio Chiefari, Dario Giuffrida
Rok vydání:	2001
Předmět:	endocrine system Pathology medicine.medical_specialty Heterozygote ret oncogene endocrine system diseases Endocrinology Diabetes and Metabolism Biology medicine.disease_cause Proto-Oncogene Mas RET Oncoprotein Thyroid carcinoma Neoplasms Multiple Primary Endocrinology Proto-Oncogene Proteins Adenocarcinoma Follicular medicine Drosophila Proteins Humans Point Mutation Thyroid Neoplasms Thyroid neoplasm Aged Mutation mixed thyroid carcinoma thyroid neoplasm Point mutation Thyroid Proto-Oncogene Proteins c-ret Receptor Protein-Tyrosine Kinases medicine.disease Immunohistochemistry medicine.anatomical_structure Medullary carcinoma Carcinoma Medullary Female
Zdroj:	Journal of endocrinological investigation. 24(1)
ISSN:	0391-4097
Popis:	A case of a patient with an uncommon thyroid carcinoma, showing histological and immunohistochemical features of both follicular and parafollicular cells is described. Somatic point mutation (ATG to ACG heterozygotic mutation at codon 918) of the RET proto-oncogene was detected in tumor tissue, as confirmed by immunohistochemical expression of RET oncoprotein. Our findings suggest that constitutive RET proto-oncogene activation may be involved in the development of mixed medullary-follicular thyroid carcinoma.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3ce0bd8620677758b5d263f316a093c https://pubmed.ncbi.nlm.nih.gov/11227733 Zobrazit plný text záznamu Full text from SpringerLink