Ginseng Berry Extract Rich in Phenolic Compounds Attenuates Oxidative Stress but not Cardiac Remodeling post Myocardial Infarction
| Autor: | Liping Yu, Jo-Ann Stebbing, Jay C. Petkau, Heather Blewett, Paramjit S. Tappia, Suvira Prashar, Yaw L. Siow, Grant N. Pierce, Daniel C. W. Brown, Mihir Parikh, Thomas Netticadan, Pema Raj |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male medicine.medical_treatment Myocardial Infarction phenolic compounds Pharmacology ginseng berry medicine.disease_cause Antioxidants lcsh:Chemistry Rats Sprague-Dawley Ginseng chemistry.chemical_compound 0302 clinical medicine Diastole Myocardial infarction lcsh:QH301-705.5 Spectroscopy medicine.diagnostic_test biology Ventricular Remodeling food and beverages Panax quinquefolius General Medicine Organ Size Malondialdehyde Computer Science Applications Cytokine medicine.anatomical_structure 030220 oncology & carcinogenesis Heart Function Tests Cytokines Erratum T cell Panax Cardiomegaly complex mixtures Article Catalysis Flow cytometry Immunophenotyping Inorganic Chemistry 03 medical and health sciences Phenols medicine Animals Physical and Theoretical Chemistry Molecular Biology American ginseng Inflammation business.industry Myocardium Organic Chemistry Body Weight biology.organism_classification medicine.disease Oxidative Stress 030104 developmental biology lcsh:Biology (General) lcsh:QD1-999 chemistry Fruit business Oxidative stress |
| Zdroj: | International Journal of Molecular Sciences Volume 20 Issue 4 International Journal of Molecular Sciences, Vol 20, Iss 4, p 983 (2019) |
| ISSN: | 1422-0067 |
| Popis: | The cardioprotective effects of ginseng root extracts have been reported. However, nothing is known about the myocardial actions of the phenolic compounds enriched in ginseng berry. Therefore, this study was undertaken to investigate the effects of American ginseng berry extract (GBE) in an experimental model of myocardial infarction (MI). Coronary artery ligation was performed on Sprague&ndash Dawley male rats to induce MI after which animals were randomized into groups receiving either distilled water or GBE intragastrically for 8 weeks. Echocardiography and assays for malondialdehyde (MDA) and TNF-&alpha were conducted. Flow cytometry was used to test the effects of GBE on T cell phenotypes and cytokine production. Although GBE did not improve the cardiac functional parameters, it significantly attenuated oxidative stress in post-MI rat hearts. GBE treatment also resulted in lower than control levels of TNF-&alpha in post-MI rat hearts indicating a strong neutralizing effect of GBE on this cytokine. However, there was no effect of GBE on the proportion of different T cell subsets or ex-vivo cytokine production. Taken together, the present study demonstrates GBE reduces oxidative stress, however no effect on cardiac structure and function in post-MI rats. Moreover, reduction of TNF-&alpha levels below baseline raises concern regarding its use as prophylactic or preventive adjunct therapy in cardiovascular disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|