Proteomic analysis identifies highly expressed plasma membrane proteins for detection and therapeutic targeting of specific breast cancer subtypes
| Autor: | Ann M. Nardulli, John R. Yates, Yvonne S. Ziegler, Patricia G. Tu, James J. Moresco |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Clinical Biochemistry Proteomic analysis lcsh:Medicine Estrogen receptor Proteomics 03 medical and health sciences 0302 clinical medicine Breast cancer Medicine Triple negative breast cancer HER2-positive breast cancer Molecular Biology Triple-negative breast cancer Individualized medicine business.industry Cell growth lcsh:R Cell migration General Medicine medicine.disease 030104 developmental biology Membrane protein 030220 oncology & carcinogenesis Cancer research Molecular Medicine Plasma membrane proteins Estrogen receptor α-positive breast cancer Personalized medicine business |
| Zdroj: | Clinical Proteomics, Vol 15, Iss 1, Pp 1-9 (2018) |
| ISSN: | 1559-0275 1542-6416 |
| DOI: | 10.1186/s12014-018-9206-0 |
| Popis: | In recent years, there has been an emphasis on personalizing breast cancer treatment in order to avoid the debilitating side effects caused by broad-spectrum chemotherapeutic drug treatment. Development of personalized medicine requires the identification of proteins that are expressed by individual tumors. Herein, we reveal the identity of plasma membrane proteins that are overexpressed in estrogen receptor α-positive, HER2-positive, and triple negative breast cancer cells. The proteins we identified are involved in maintaining protein structure, intracellular homeostasis, and cellular architecture; enhancing cell proliferation and invasion; and influencing cell migration. These proteins may be useful for breast cancer detection and/or treatment. |
| Databáze: | OpenAIRE |
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