Systemic sclerosis is an independent risk factor for increased coronary artery calcium deposition
| Autor: | Sonny Sau Hin Chiu, Lawrence S. C. Law, A. W. K. Tso, Mo Yin Mok, Ka Fung Mak, Chak Sing Lau, Woon Sing Wong, Y Lo, Peh Lan Khong, Karen S.L. Lam |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Carotid Artery Common Immunology Coronary Artery Disease chemistry.chemical_compound Rheumatology Risk Factors Internal medicine Odds Ratio medicine Humans Immunology and Allergy Pharmacology (medical) Endothelial dysfunction Risk factor Coronary atherosclerosis Aged Scleroderma Systemic medicine.diagnostic_test Cholesterol business.industry Calcinosis Odds ratio Middle Aged medicine.disease Radiography Logistic Models Blood pressure Endocrinology chemistry Erythrocyte sedimentation rate Cardiology Female business Body mass index |
| Zdroj: | Arthritis & Rheumatism. 63:1387-1395 |
| ISSN: | 0004-3591 |
| Popis: | Objective Endothelial dysfunction and inflammation are pathogenic mechanisms common to systemic sclerosis (SSc) and atherosclerosis. This study was undertaken to examine the relationship between coronary atherosclerosis, as assessed by the coronary artery calcium score (CACS), and conventional cardiovascular and disease-specific risk factors in SSc patients. Methods The CACS was measured by computed tomography, and cardiovascular risk factors were examined in SSc patients and compared with controls matched for age, sex, and glycemic status. Disease activity score, antiphospholipid antibodies, high-sensitivity C-reactive protein level, and erythrocyte sedimentation rate were measured in SSc patients. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were determined. Results We recruited 53 SSc patients (50 women and 3 men) and 106 controls. The patients had a mean ± SD age of 53.1 ± 12.9 years and a median disease duration of 9 years. Compared to controls, SSc patients had significantly lower low-density lipoprotein (LDL) cholesterol levels (P = 0.001), high-density lipoprotein cholesterol levels (P = 0.01), diastolic blood pressure, waist circumference, and body mass index and were more likely to be receiving vasodilators (all P < 0.001). There was a significantly higher proportion of SSc patients among subjects with more severe coronary calcification (CACS ≥101) compared to those with lesser severity (CACS |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text