3D GRASE arterial spin labelling reveals an inverse correlation of cortical perfusion with the white matter lesion volume in MS
| Autor: | Achim Gass, Michael Amann, Lutz Achtnichts, Jochen G. Hirsch, Yvonne Naegelin, Katrin Weier, Ernst-Wilhelm Radue, Ludwig Kappos, Alain Thöni, Johannes Gregori, Nicole Mueller-Lenke, Matthias Günther |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Coefficient of determination Perfusion Imaging White matter Disability Evaluation Young Adult Atrophy Nuclear magnetic resonance Multiple Sclerosis Relapsing-Remitting Leukoencephalopathies Predictive Value of Tests Linear regression medicine Humans Aged Cerebral Cortex medicine.diagnostic_test business.industry Multiple sclerosis Magnetic resonance imaging Middle Aged Multiple Sclerosis Chronic Progressive medicine.disease Magnetic Resonance Imaging medicine.anatomical_structure Neurology Cerebral blood flow Regional Blood Flow Predictive value of tests Cerebrovascular Circulation Multivariate Analysis Linear Models Female Spin Labels Neurology (clinical) Nuclear medicine business Blood Flow Velocity |
| Zdroj: | Multiple sclerosis (Houndmills, Basingstoke, England). 18(11) |
| ISSN: | 1477-0970 |
| Popis: | Background: We hypothesized that in multiple sclerosis (MS) patients, reduced cortical perfusion is associated with chronic white matter injury. Objective: To investigate the influence of different clinical and magnetic resonance imaging characteristics on cortical perfusion. Methods: Cerebral blood flow (CBF) was assessed by applying a pulsed arterial spin labelling (ASL) technique combined with single-shot 3D-GRASE (gradient-spin echo) in a cohort of 165 MS patients with a relapsing–remitting ( n=123) or secondary progressive disease course ( n=42). Mean age was 45.4 years (20–68 years), mean disease duration was 14.2 years (1–48 years). Results: Mean cortical CBF was 45.6 ml/100g per min (SD: 7.8 ml/100g per min). Stepwise multiple linear regression models were calculated to investigate the relationship between different factor sets and mean CBF. The model with the highest adjusted coefficient of determination included T2 lesion load, age, gender and disease duration as significant factors. Post-hoc Spearman rank correlation revealed significant correlation of adjusted CBF with T2 lesion load (t=−0.35, p=1*10–6), with age (t =−0.34, p=4*10–6), and with disease duration (t=0.16, p=0.03), while Expanded Disability Status Scale (EDSS) did not reach significance in either model. Conclusion: This study suggests that the amount of white matter lesions indicates a reduced metabolic demand and reduced perfusion at a cortical level. |
| Databáze: | OpenAIRE |
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