Alterations in regulatory T cells induced by specific oligosaccharides improve vaccine responsiveness in mice
| Autor: | Kirsten Szklany, Belinda Van't Land, JoAnn Kerperien, Jacqueline Bastiaans, Louis Boon, Jenny Meerding, Johan Garssen, Gerard A. Hofman, Marcel A. Schijf, Femke van Wijk |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
Regulatory T cell Science Population Oligosaccharides Spleen chemical and pharmacologic phenomena GATA3 Transcription Factor Biology CXCR3 T-Lymphocytes Regulatory Mice Immune system Orthomyxoviridae Infections medicine Mesenteric lymph nodes Animals Hypersensitivity Delayed IL-2 receptor education education.field_of_study Multidisciplinary Vaccination FOXP3 hemic and immune systems Th1 Cells Flow Cytometry Orthomyxoviridae Mice Inbred C57BL medicine.anatomical_structure Immunology Dietary Supplements Medicine T-Box Domain Proteins Research Article |
| Zdroj: | PLoS ONE, Vol 8, Iss 9, p e75148 (2013) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | UnlabelledProphylactic vaccinations are generally performed to protect naïve individuals with or without suppressed immune responsiveness. In a mouse model for Influenza vaccinations the specific alterations of CD4(+)CD25(+)Foxp3(+) regulatory T-cells (Tregs) in the immune modulation induced by orally supplied oligosaccharides containing scGOS/lcFOS/pAOS was assessed. This dietary intervention increased vaccine specific DTH responses. In addition, a significant increased percentage of T-bet(+) (Th1) activated CD69(+)CD4(+) T cells (pIn conclusionThese data are indicative for improved vaccine responsiveness due to reduced Th1 suppressive capacity in the Treg population of mice fed the oligosaccharide specific diet, showing compartmentalization within the Treg population. The modulation of Tregs to control immune responses provides an additional arm of intervention using alternative strategies possibly leading to the development of improved vaccines. |
| Databáze: | OpenAIRE |
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