Bacterial MgrB peptide activates chemoreceptor Fpr3 in mouse accessory olfactory system and drives avoidance behaviour
Autor: | Günter Lochnit, Yannick Teuchert, Tomohiro Ishii, Markus Bischoff, Janina Eisenbeis, Anabel Pérez-Gómez, Thomas Timm, Andreas Schmid, Peter Mombaerts, Bernd Bufe, Trese Leinders-Zufall, Frank Zufall, Martina Pyrski |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Signal peptide Olfactory system Chemoreceptor Vomeronasal organ Sensory Receptor Cells Science Regulator General Physics and Astronomy Biology General Biochemistry Genetics and Molecular Biology Article 03 medical and health sciences Mice 0302 clinical medicine Bacterial Proteins Enterobacteriaceae Avoidance Learning Animals Receptor lcsh:Science Multidisciplinary Formyl peptide receptor Innate immune system Escherichia coli Proteins fungi Membrane Proteins General Chemistry Receptors Formyl Peptide Cell biology 030104 developmental biology nervous system lcsh:Q Vomeronasal Organ human activities 030217 neurology & neurosurgery Neuroscience circulatory and respiratory physiology |
Zdroj: | Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019) Nature Communications |
ISSN: | 2041-1723 |
Popis: | Innate immune chemoreceptors of the formyl peptide receptor (Fpr) family are expressed by vomeronasal sensory neurons (VSNs) in the accessory olfactory system. Their biological function and coding mechanisms remain unknown. We show that mouse Fpr3 (Fpr-rs1) recognizes the core peptide motif f-MKKFRW that is predominantly present in the signal sequence of the bacterial protein MgrB, a highly conserved regulator of virulence and antibiotic resistance in Enterobacteriaceae. MgrB peptide can be produced and secreted by bacteria, and is selectively recognized by a subset of VSNs. Exposure to the peptide also stimulates VSNs in freely behaving mice and drives innate avoidance. Our data shows that Fpr3 is required for neuronal detection and avoidance of peptides derived from a conserved master virulence regulator of enteric bacteria. The role of chemoreceptors on vomeronasal neurons are not fully understood. Here the authors show that in mice, the vomeronasal chemoreceptor Fpr3 responds to peptides from the bacterial MgrB protein, and that exposure to these peptides drives an avoidance response. |
Databáze: | OpenAIRE |
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