Regulation of adrenal cell-differentiated functions by growth factors
| Autor: | I. Viard, Armelle Penhoat, W.E. Rainey, J.M. Saez |
|---|---|
| Přispěvatelé: | Communications Cellulaires et Différenciation (CCD), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM), ProdInra, Migration |
| Jazyk: | angličtina |
| Rok vydání: | 1994 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism medicine.medical_treatment [SDV]Life Sciences [q-bio] 030209 endocrinology & metabolism 03 medical and health sciences 0302 clinical medicine Endocrinology Transforming Growth Factor beta Internal medicine Adrenal Glands medicine Animals Insulin-Like Growth Factor I Growth Substances TGF beta 1 ComputingMilieux_MISCELLANEOUS 030304 developmental biology 0303 health sciences biology Growth factor food and beverages Cell Differentiation Somatomedin TGF [SDV] Life Sciences [q-bio] biology.protein Adrenal cell Transforming growth factor |
| Zdroj: | Hormone Research Hormone Research, Karger, 1994, 42, pp.39-43 |
| ISSN: | 0301-0163 1423-0046 |
| Popis: | Adrenal cell-differentiated functions and, therefore, their steroidogenic capacity can be regulated in an opposite direction by insulin-like growth factor I (IGF-I) and transforming growth factor-beta 1 (TGF beta 1). The enhanced steroidogenic responsiveness of bovine and ovine adrenal cells treated with IGF-I can be explained by its positive effects on the number of corticotropin (ACTH) and angiotensin II (A-II) receptors associated with an increase in the alpha s and alpha i subunits of G proteins but also by its effects on several steps of the steroidogenic pathway. In contrast, TGF beta 1 is a potent inhibitor of differentiated functions of both bovine and ovine adrenal cells. TGF beta 1 reduces ACTH and A-II receptor number, inhibits cAMP formation, and decreases several steroidogenic enzyme activities. The physiological role of these peptides in adrenal cells is strengthened by the fact that both are synthetized and secreted by these cells and that their secretion can be regulated by the specific hormones, ACTH and A-II. |
| Databáze: | OpenAIRE |
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