Genetic susceptibility for major depressive disorder associates with trajectories of depressive symptoms across childhood and adolescence
| Autor: | Matt Hawrilenko, Erin C. Dunn, Karmel W. Choi, Yiwen Zhu, Min-Jung Wang, Alexandre A. Lussier, Janine Cerutti |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Longitudinal study Adolescent Early adolescence Depressive Disorder Major/epidemiology Article 03 medical and health sciences 0302 clinical medicine Developmental and Educational Psychology medicine Genetic predisposition Humans 0501 psychology and cognitive sciences Genetic Predisposition to Disease Longitudinal Studies Prospective Studies Symptom onset Genetic risk Child Depressive symptoms Depression (differential diagnoses) Depressive Disorder Major Depression business.industry Genetic Predisposition to Disease/genetics 05 social sciences medicine.disease 030227 psychiatry Psychiatry and Mental health Pediatrics Perinatology and Child Health Major depressive disorder Polygenic risk score Psychology business 030217 neurology & neurosurgery 050104 developmental & child psychology Demography Genome-Wide Association Study Clinical psychology |
| Zdroj: | J Child Psychol Psychiatry Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium 2021, ' Genetic susceptibility for major depressive disorder associates with trajectories of depressive symptoms across childhood and adolescence ', Journal of Child Psychology & Psychiatry, vol. 62, no. 7, pp. 895-904 . https://doi.org/10.1111/jcpp.13342 |
| DOI: | 10.1101/2020.03.02.19007088 |
| Popis: | BackgroundEarly-onset depression during childhood and adolescence is associated with a worse course of illness and outcome than adult onset. However, the genetic factors that influence risk for early-onset depression remain mostly unknown. Using data collected over 13 years, we examined whether polygenic risk scores (PRS) that capture genetic risk for depression were associated with depression trajectories assessed from childhood to adolescence.MethodsData came from the Avon Longitudinal Study of Parents and Children, a prospective, longitudinal birth cohort (analytic sample=7,308 youth). We analyzed the relationship between genetic susceptibility to depression and three time-dependent measures of depressive symptoms trajectories spanning 4 to 16.5 years of age (class, onset, and cumulative burden). Trajectories were constructed using a growth mixture model with structured residuals. PRS were generated from the summary statistics of a genome-wide association study of depression risk using data from the Psychiatric Genomics Consortium, UK Biobank, and 23andme, Inc. We used MAGMA to identify gene-level associations with these measures.ResultsYouth were classified into 6 classes of depressive symptom trajectories: high/renitent (26.5% of youth), high/reversing (5.8%), childhood decrease (6.1%), late childhood peak (3%), adolescent spike (2.5%), and minimal symptoms (56.1%). PRS discriminated between youth in the late childhood peak, high/reversing, and high/renitent classes compared to the minimal symptoms and childhood decrease classes. No significant associations were detected at the gene level.ConclusionsThis study highlights differences in polygenic loading for depressive symptoms across childhood and adolescence, particularly among youths with high symptoms in early adolescence, regardless of age-independent patterns. |
| Databáze: | OpenAIRE |
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