Procalcitonin accurately predicts lung transplant adults with low risk of pulmonary graft dysfunction and intensive care mortality
| Autor: | Bárbara Borgatta, Jordi Rello, Alberto Sandiumenge, C. Mazo, Antonio Roman, Teresa Pont, Silvia Moyano |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Graft dysfunction medicine.medical_specialty Critical Care medicine.medical_treatment Primary Graft Dysfunction 030204 cardiovascular system & hematology 030230 surgery Critical Care and Intensive Care Medicine Graft function Gastroenterology Procalcitonin 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Intensive care Internal medicine Odds Ratio medicine Humans Lung transplantation Hospital Mortality Prospective Studies Lung business.industry Interleukins Oxygenation Middle Aged respiratory system Surgery Oxygen Intensive Care Units medicine.anatomical_structure Multivariate Analysis Female business Biomarkers hormones hormone substitutes and hormone antagonists Lung Transplantation |
| Zdroj: | Journal of Critical Care. 44:142-147 |
| ISSN: | 0883-9441 |
| Popis: | We evaluated the association of procalcitonin (PCT), IL-6-8-10 plasma levels during the first 72h after lung transplantation (LT) with ICU-mortality, oxygenation, primary graft dysfunction (PGD), and one-year graft function after LT.Prospective, observational study. PCT and IL-6-8-10 plasma levels were measured at 24h, 48h and 72h after LT from 100 lung transplant recipients (LTr). Patients were followed until one year after LT. End-points were ICU survival, grade 3 PGD at 72h and one-year graft function.Higher PCT at 24h was associated with lower PaOA breakpoint of PCT2ng/mL within 24h has a high predictive value to exclude grade 3 PGD at 72h and for ICU survival. Moreover, both PCT and IL-10 within 48h were associated with significantly better graft function one year after surgery. |
| Databáze: | OpenAIRE |
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