Interlaboratory Comparison on the Quantification of Total and Accessible Amine Groups on Silica Nanoparticles with qNMR and Optical Assays
| Autor: | Ying Sun, Bastian Rühle, Nithiya Nirmalananthan-Budau, Linda J. Johnston, Ute Resch-Genger, Filip Kunc |
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| Rok vydání: | 2021 |
| Předmět: |
assays
Chemistry Context (language use) 02 engineering and technology Reference Standards Silicon Dioxide 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Nanostructures 0104 chemical sciences Analytical Chemistry Nanomaterials Silica nanoparticles silica Nanoparticles Amine gas treating Biochemical engineering Amines 0210 nano-technology nanomaterials |
| Zdroj: | Analytical Chemistry. 93:15271-15278 |
| ISSN: | 1520-6882 0003-2700 |
| Popis: | Risk assessment of nanomaterials requires not only standardized toxicity studies but also validated methods for nanomaterial surface characterization with known uncertainties. In this context, a first bilateral interlaboratory comparison on surface group quantification of nanomaterials is presented that assesses different reporter-free and labeling methods for the quantification of the total and accessible number of amine functionalities on commercially available silica nanoparticles that are widely used in the life sciences. The overall goal of this comparison is the identification of optimum methods as well as achievable measurement uncertainties and the comparability of the results across laboratories. We also examined the robustness and ease of implementation of the applied analytical methods and discussed method-inherent limitations. In summary, this comparison presents a first step toward the eventually required standardization of methods for surface group quantification. |
| Databáze: | OpenAIRE |
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