Heterogeneous expression of ACE2 and TMPRRS2 in mesenchymal stromal cells

Autor: Simon P. Hoerstrup, Michal J. Okoniewski, Debora Kehl, Melanie Generali, Paolo Cinelli, Debora Wanner
Přispěvatelé: University of Zurich
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Short Communication
Primary Cell Culture
Cell- and Tissue-Based Therapy
Short Communications
Adipose tissue
Bone Marrow Cells
610 Medicine & health
Mesenchymal Stem Cell Transplantation
adult stem cells
Proinflammatory cytokine
Umbilical Cord
Cell therapy
Immune system
medicine
sars‐CoV‐2
Humans
business.industry
Gene Expression Profiling
Mesenchymal stem cell
Serine Endopeptidases
COVID-19
Mesenchymal Stem Cells
Cell Biology
cellular therapy
11359 Institute for Regenerative Medicine (IREM)
medicine.disease
mesenchymal stromal cells (MSCs)
10021 Department of Trauma Surgery
medicine.anatomical_structure
sars-CoV-2
Adipose Tissue
Gene Expression Regulation
Immunology
Spike Glycoprotein
Coronavirus
Molecular Medicine
Bone marrow
Angiotensin-Converting Enzyme 2
business
Cytokine storm
Cytokine Release Syndrome
Adult stem cell
Protein Binding
Zdroj: Journal of Cellular and Molecular Medicine, 26 (1)
Journal of Cellular and Molecular Medicine
ISSN: 1582-1838
1582-4934
DOI: 10.5167/uzh-209946
Popis: The outbreak of COVID-19 has become a serious public health emergency. The virus targets cells by binding the ACE2 receptor. After infection, the virus triggers in some humans an immune storm containing the release of proinflammatory cytokines and chemokines followed by multiple organ failure. Several vaccines are enrolled, but an effective treatment is still missing. Mesenchymal stem cells (MSCs) have shown to secrete immunomodulatory factors that suppress this cytokine storm. Therefore, MSCs have been suggested as a potential treatment option for COVID-19. We report here that the ACE2 expression is minimal or nonexistent in MSC derived from three different human tissue sources (adipose tissue, umbilical cord Wharton`s jelly and bone marrow). In contrast, TMPRSS2 that is implicated in SARS-CoV-2 entry has been detected in all MSC samples. These results are of particular importance for future MSC-based cell therapies to treat severe cases after COVID-19 infection.
Journal of Cellular and Molecular Medicine, 26 (1)
ISSN:1582-1838
ISSN:1582-4934
Databáze: OpenAIRE
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