Preexisting subtype immunodominance shapes memory B cell recall response to influenza vaccination
| Autor: | Greg A. Kirchenbaum, Ted M. Ross, Emily F. Clutter, Rodrigo B. Abreu, Giuseppe A. Sautto |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male 0301 basic medicine Antigenicity Adolescent Hemagglutinin Glycoproteins Influenza Virus Immunodominance Antibodies Viral Young Adult 03 medical and health sciences 0302 clinical medicine Immune system Influenza Human Humans Medicine Memory B cell Pathogen Aged Aged 80 and over B-Lymphocytes biology business.industry Influenza A Virus H3N2 Subtype Vaccination Immunity General Medicine Middle Aged United States 030104 developmental biology Influenza Vaccines Infectious disease (medical specialty) Immunoglobulin G 030220 oncology & carcinogenesis Immunology biology.protein Female Antibody business Immunologic Memory Research Article |
| Zdroj: | JCI Insight. 5 |
| ISSN: | 2379-3708 |
| DOI: | 10.1172/jci.insight.132155 |
| Popis: | Influenza is a highly contagious viral pathogen with more than 200,000 cases reported in the United States during the 2017-2018 season. Annual vaccination is recommended by the World Health Organization, with the goal to reduce influenza severity and transmission. Currently available vaccines are about 60% effective, and vaccine effectiveness varies from season to season, as well as between different influenza subtypes within a single season. Immunological imprinting from early-life influenza infection can prominently shape the immune response to subsequent infections. Here, the impact of preexisting B cell memory in the response to quadrivalent influenza vaccine was assessed using blood samples collected from healthy subjects (18-85 years old) prior to and 21-28 days following influenza vaccination. Influenza vaccination increased both HA-specific antibodies and memory B cell frequency. Despite no apparent differences in antigenicity between vaccine components, most individuals were biased toward one of the vaccine strains. Specifically, responses to H3N2 were reduced in magnitude relative to the other vaccine components. Overall, this study unveils a potentially new mechanism underlying differential vaccine effectiveness against distinct influenza subtypes. |
| Databáze: | OpenAIRE |
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