The role of prostaglandin and antioxidant availability in recovery from forearm ischemia-reperfusion injury in humans
| Autor: | Mark Rakobowchuk, Sophie E. Carter, Ashton Faulkner |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
Brachial Artery Physiology Ibuprofen Ascorbic Acid Ibuprofin Antioxidants chemistry.chemical_compound shear rate Open access publishing ORIGINAL PAPERS: Pathophysiological aspects Vitamin E flow-mediated dilation Allometric scaling Ultrasonography Thioctic Acid Forearm Injuries Creative commons Prostaglandin antagonist Vasodilation Flow-mediated dilation Forearm medicine.anatomical_structure Anesthesia Reperfusion Injury Female Cardiology and Cardiovascular Medicine Blood Flow Velocity allometric scaling Adult Prostaglandin Antagonists Low flow-mediated constriction Shear rate Ischemia Prostaglandin Young Adult Internal Medicine medicine Humans business.industry Hemodynamics medicine.disease Ascorbic acid low flow-mediated constriction chemistry Prostaglandins Endothelium Vascular business Reperfusion injury |
| Zdroj: | Journal of Hypertension |
| Popis: | This article is made available through the Brunel Open Access Publishing Fund. It is shared under the Creative Commons License Attribution-Noncommercial No Derivative 3.0 (CCBY NCND). Copyright @ Lippincott Williams & Wilkins. Background: Endothelial dysfunction, manifesting as attenuated flow-mediated dilation (FMD), is clinically important. Antioxidants may prevent this dysfunction; however, the acute effects of oral administration in humans are unknown. Low flow-mediated constriction (L-FMC), a further parameter of endothelial health, is largely unstudied and the mechanisms for this response unclear. Methods: Twelve healthy participants (five women and seven men) completed three test conditions: control; antioxidant cocktail (α-lipoic acid, vitamins C and E); and prostaglandin inhibitor ingestion (ibuprofen). Ultrasound measurements of brachial artery responses were assessed throughout 5 min of forearm ischemia and 3 min after. Subsequently, an ischemia–reperfusion injury was induced by a 20-min upper arm occlusion. Further, vascular function protocols were completed at 15, 30, and 45 min of recovery. Results: Endothelial dysfunction was evident in all conditions. FMD was attenuated at 15 min after ischemia–reperfusion injury (Pre: 6.24 ± 0.58%; Post15: 0.24 ± 0.75%; mean ± SD, P 0.05). The magnitude of L-FMC was augmented at 15 min (Pre: 1.44 ± 0.27%; Post15: 3.75 ± 1.73%; P |
| Databáze: | OpenAIRE |
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