Subcortical surface morphometry in substance dependence: An ENIGMA addiction working group study
| Autor: | Neda Jahanshad, Christopher R.K. Ching, Yann Chye, Anna E. Goudriaan, Ozlem Korucuoglu, Albert Batalla, Angelica M. Morales, Scott Mackey, Nadia Solowij, Catherine Orr, Edythe D. London, Dan J. Stein, John J. Foxe, Ruth J. van Holst, Godfrey D. Pearlson, Janna Cousijn, Liesbeth Reneman, Valentina Lorenzetti, Robert Hester, Patricia J. Conrod, Shashwath A. Meda, Alain Dagher, Rajita Sinha, Samantha J. Brooks, Paul M. Thompson, Boris A. Gutman, Chiang-Shan R. Li, Maartje Luijten, Kent E. Hutchison, Murat Yücel, Dick J. Veltman, Lianne Schmaal, Anne Uhlmann, Elliot A. Stein, Hugh Garavan, Reinout W. Wiers, Elisabeth C. Caparelli, Rocío Martín-Santos, Antonio Verdejo-García, Anne Marije Kaag, Sara K. Blaine, Reza Momenan, Martin P. Paulus, Deborah Tang |
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| Přispěvatelé: | Ontwikkelingspsychologie (Psychologie, FMG), Psychology Other Research (FMG), Amsterdam Neuroscience - Brain Imaging, Psychiatry, Anatomy and neurosciences, Adult Psychiatry, ANS - Compulsivity, Impulsivity & Attention, APH - Personalized Medicine, APH - Mental Health, Radiology and Nuclear Medicine, APH - Digital Health, Radiology & Nuclear Medicine, Clinical Neuropsychology |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Nicotine Adolescent Substance-Related Disorders Medicine (miscellaneous) Neuroimaging Amygdala Medical and Health Sciences Article Methamphetamine 03 medical and health sciences Young Adult 0302 clinical medicine Cocaine SDG 3 - Good Health and Well-being substance dependence medicine Humans structural MRI Cannabis Pharmacology Substance dependence Ethanol business.industry Putamen Brain morphometry Alcohol dependence Psychology and Cognitive Sciences Substance Abuse Brain 16. Peace & justice medicine.disease Magnetic Resonance Imaging 030227 psychiatry Psychiatry and Mental health medicine.anatomical_structure RC0321 Female addiction business Neuroscience Developmental Psychopathology 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Addiction biology, vol 25, iss 6 Addiction Biology, 25, 6 Chye, Y, Mackey, S, Gutman, B A, Ching, C R K, Batalla, A, Blaine, S, Brooks, S, Caparelli, E C, Cousijn, J, Dagher, A, Foxe, J J, Goudriaan, A E, Hester, R, Hutchison, K, Jahanshad, N, Kaag, A M, Korucuoglu, O, Li, C-S R, London, E D, Lorenzetti, V, Luijten, M, Martin-Santos, R, Meda, S A, Momenan, R, Morales, A, Orr, C, Paulus, M P, Pearlson, G, Reneman, L, Schmaal, L, Sinha, R, Solowij, N, Stein, D J, Stein, E A, Tang, D, Uhlmann, A, van Holst, R, Veltman, D J, Verdejo-Garcia, A, Wiers, R W, Yuecel, M, Thompson, P M, Conrod, P & Garavan, H 2020, ' Subcortical surface morphometry in substance dependence: An ENIGMA addiction working group study ', Addiction Biology, vol. 25, no. 6, e12830, pp. 1-15 . https://doi.org/10.1111/adb.12830 Addiction Biology, 25 Addict Biol Addiction Biology, 25(6):e12830. Wiley-Blackwell Addiction biology, 25(6):e12830. Wiley-Blackwell Addiction Biology, 25(6):e12830, 1-15. Wiley-Blackwell Chye, Y, Mackey, S, Gutman, B A, Ching, C R K, Batalla, A, Blaine, S, Brooks, S, Caparelli, E C, Cousijn, J, Dagher, A, Foxe, J J, Goudriaan, A E, Hester, R, Hutchison, K, Jahanshad, N, Kaag, A M, Korucuoglu, O, Li, C-S R, London, E D, Lorenzetti, V, Luijten, M, Martin-Santos, R, Meda, S A, Momenan, R, Morales, A, Orr, C, Paulus, M P, Pearlson, G, Reneman, L, Schmaal, L, Sinha, R, Solowij, N, Stein, D J, Stein, E A, Tang, D, Uhlmann, A, van Holst, R, Veltman, D J, Verdejo-Garcia, A, Wiers, R W, Yücel, M, Thompson, P M, Conrod, P & Garavan, H 2020, ' Subcortical surface morphometry in substance dependence: An ENIGMA addiction working group study ', Addiction Biology, vol. 25, no. 6, e12830 . https://doi.org/10.1111/adb.12830 |
| ISSN: | 1369-1600 1355-6215 |
| Popis: | Contains fulltext : 219494.pdf (Publisher’s version ) (Closed access) While imaging studies have demonstrated volumetric differences in subcortical structures associated with dependence on various abused substances, findings to date have not been wholly consistent. Moreover, most studies have not compared brain morphology across those dependent on different substances of abuse to identify substance-specific and substance-general dependence effects. By pooling large multinational datasets from 33 imaging sites, this study examined subcortical surface morphology in 1628 nondependent controls and 2277 individuals with dependence on alcohol, nicotine, cocaine, methamphetamine, and/or cannabis. Subcortical structures were defined by FreeSurfer segmentation and converted to a mesh surface to extract two vertex-level metrics - the radial distance (RD) of the structure surface from a medial curve and the log of the Jacobian determinant (JD) - that, respectively, describe local thickness and surface area dilation/contraction. Mega-analyses were performed on measures of RD and JD to test for the main effect of substance dependence, controlling for age, sex, intracranial volume, and imaging site. Widespread differences between dependent users and nondependent controls were found across subcortical structures, driven primarily by users dependent on alcohol. Alcohol dependence was associated with localized lower RD and JD across most structures, with the strongest effects in the hippocampus, thalamus, putamen, and amygdala. Meanwhile, nicotine use was associated with greater RD and JD relative to nonsmokers in multiple regions, with the strongest effects in the bilateral hippocampus and right nucleus accumbens. By demonstrating subcortical morphological differences unique to alcohol and nicotine use, rather than dependence across all substances, results suggest substance-specific relationships with subcortical brain structures. 15 p. |
| Databáze: | OpenAIRE |
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