Monoclonal antibodies against hepatitis A virus
| Autor: | A G Coulepis, Stephen Locarnini, M Kornitschuk, A MacGregor, Noreen I. Lehmann, J G Hurrell, Ian D. Gust |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1983 |
| Předmět: |
Microbiology (medical)
biology medicine.drug_class Antibodies Monoclonal Radioimmunoassay Monoclonal antibody Primary and secondary antibodies Virology Immunoglobulin G Neutralization Mice Microscopy Electron Antigen Antibody Specificity Monoclonal biology.protein medicine Immunologic Techniques Animals Humans Hepatovirus Antibody Research Article |
| Popis: | Three monoclonal antibodies (K2-4F2, K3-2F2, and K3-4C8) of the immunoglobulin G2a class were raised against hepatitis A virus. The specificity of these antibodies was confirmed by immune electron microscopy, solid-phase radioimmunoassay, and in vitro neutralization in cell culture. Binding studies suggested that they all recognize closely related antigenic determinants. These monoclonal antibodies should prove to be of great value as diagnostic and research reagents. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|