Feroptoza: regulirana stanična smrt
| Autor: | Ivana Čepelak, Slavica Dodig, Daniela Čepelak Dodig |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Programmed cell death Traumatic brain injury Iron lipidna peroksidacija system Xc− Biology Toxicology GPX4 medicine.disease_cause glutathione peroxidase 4 iron lipid peroxidation reactive oxygen species system XcČepelak Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Ferroptosis reaktivne kisikove vrste glutation peroksidaza 4 sustav Xc željezo chemistry.chemical_classification Reactive oxygen species Cell Death Public Health Environmental and Occupational Health Cancer reaktivne kisikove vrste sustav Xc medicine.disease 030104 developmental biology chemistry 030220 oncology & carcinogenesis Cancer research Original Article Carcinogenesis Polyunsaturated fatty acid |
| Zdroj: | Arhiv za higijenu rada i toksikologiju Volume 71 Issue 2 Archives of Industrial Hygiene and Toxicology |
| ISSN: | 1848-6312 0004-1254 |
| Popis: | Ferroptosis is a recently identified form of regulated cell death that differs from other known forms of cell death morphologically, biochemically, and genetically. The main properties of ferroptosis are free redox-active iron and consequent iron-dependent peroxidation of polyunsaturated fatty acids in cell membrane phospholipids, which results in the accumulation of lipid-based reactive oxygen species due to loss of glutathione peroxidase 4 activity. Ferroptosis has increasingly been associated with neurodegenerative diseases, carcinogenesis, stroke, intracerebral haemorrhage, traumatic brain injury, and ischemia-reperfusion injury. It has also shown a significant therapeutic potential in the treatment of cancer and other diseases. This review summarises current knowledge about and the mechanisms that regulate ferroptosis. Feroptoza je nedavno identificirani oblik regulirane stanične smrti koji se od ostalih poznatih oblika stanične smrti razlikuje morfološki, biokemijski i genetski. Glavna svojstva feroptoze uključuju slobodno redoks aktivno željezo i posljedičnu, o željezu ovisnu, peroksidaciju polinezasićenih masnih kiselina u fosfolipidima staničnih membrana te gubitak aktivnosti glutation peroksidaze 4, što rezultira akumulacijom lipidnih, reaktivnih kisikovih spojeva. Feroptoza se sve više povezuje s raznim bolestima kao što su neurodegenerativne bolesti, karcinom, moždani udar, intracerebralna krvarenja, traumatične ozljede mozga i ishemijsko-reperfuzijska ozljeda. Također je pokazan značajan terapijski potencijal u liječenju raka i drugih bolesti. Ovaj pregled sažima trenutačne spoznaje i mehanizme koji reguliraju feroptozu. |
| Databáze: | OpenAIRE |
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