Correlation of carotid artery reactivity with cardiovascular risk factors and coronary artery vasodilator responses in asymptomatic, healthy volunteers
| Autor: | Frederieke van Oorschot, Anke C.C.M. van Mil, Maria T. E. Hopman, David Oxborough, Nicola D. Hopkins, Nikki Bax, Ellen A. Dawson, Annemieke Heemels, Dick H. J. Thijssen, Yvonne A. W. Hartman, Daniel J. Green |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Physiology Vasodilation 030204 cardiovascular system & hematology Carotid Intima-Media Thickness RC1200 Correlation 0302 clinical medicine Risk Factors Young adult Human Nutrition & Health Aged 80 and over Ultrasound Humane Voeding & Gezondheid Cold pressor test Age Factors Middle Aged Coronary Vessels Healthy Volunteers Cold Temperature medicine.anatomical_structure Carotid Arteries Cardiovascular Diseases Cardiology Female medicine.symptom Cardiology and Cardiovascular Medicine Blood Flow Velocity Artery Adult medicine.medical_specialty Asymptomatic 03 medical and health sciences Young Adult Coronary arteries Internal medicine Carotid artery reactivity test Internal Medicine medicine Humans Aged business.industry Metabolic Disorders Radboud Institute for Health Sciences [Radboudumc 6] Endothelial function Cardiovascular risk business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Hypertension, 35, 1026-1034 Journal of Hypertension, 35(5), 1026-1034 Journal of Hypertension, 35, 5, pp. 1026-1034 Journal of Hypertension 35 (2017) 5 |
| ISSN: | 0263-6352 |
| DOI: | 10.1097/hjh.0000000000001274 |
| Popis: | Contains fulltext : 173074.pdf (Publisher’s version ) (Closed access) OBJECTIVES: Carotid artery reactivity (CAR%), involving carotid artery diameter responses to a cold pressor test (CPT), is a noninvasive measure of conduit artery function in humans. This study examined the impact of age and cardiovascular risk factors on the CAR% and the relationship between CAR% and coronary artery vasodilator responses to the CPT. METHODS: Ultrasound was used to measure resting and peak carotid artery diameters during the CPT, with CAR% being calculated as the relative change from baseline (%). We compared CAR% between young (n = 50, 24 +/- 3 years) and older participants (n = 44, 61 +/- 8 years), and subsequently assessed relationships between CAR% and traditional cardiovascular risk factors in 50 participants (44 +/- 21 years). Subsequently, we compared left anterior descending (LAD) artery velocity (using transthoracic Doppler) with carotid artery diameter (i.e. CAR%) during the CPT (n = 33, 37 +/- 17 years). RESULTS: A significantly larger CAR% was found in young versus older healthy participants (4.1 +/- 3.7 versus 1.8 +/- 2.6, P < 0.001). Participants without cardiovascular risk factors demonstrated a higher CAR% than those with at least two risk factors (2.9 +/- 2.9 versus 0.5 +/- 2.9, P = 0.019). Carotid artery diameter and LAD velocity increased during CPT (P < 0.001). Carotid diameter and change in velocity correlated with LAD velocity (r = 0.486 and 0.402, P < 0.004 and 0.02, respectively). CONCLUSION: Older age and cardiovascular risk factors are related to lower CAR%, while CAR% shows good correlation with coronary artery responses to the CPT. Therefore, CAR% may represent a valuable technique to assess cardiovascular risk, while CAR% seems to reflect coronary artery vasodilator function. 01 mei 2017 |
| Databáze: | OpenAIRE |
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