Routine revascularization with percutaneous coronary intervention in patients with coronary artery disease undergoing transcatheter aortic valve implantation - the third nordic aortic valve intervention trial - NOTION-3

Autor:	Muhammad Sabbah, Karsten Veien, Matti Niemela, Phillip Freeman, Rickard Linder, Dan Ioanes, Christian Juhl Terkelsen, Olli A. Kajander, Sasha Koul, Mikko Savontaus, Pasi Karjalainen, Andrejs Erglis, Mikko Minkkinen, Troels Jørgensen, Lars Sondergaard, Ole De Backer, Thomas Engstrøm, Jacob Lønborg
Přispěvatelé:	Tampere University, Clinical Medicine, TAYS Heart Centre
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	3121 Internal medicine Cardiology and Cardiovascular Medicine
Zdroj:	Sabbah, M, Veien, K, Niemela, M, Freeman, P, Linder, R, Ioanes, D, Terkelsen, C J, Kajander, O A, Koul, S, Savontaus, M, Karjalainen, P, Erglis, A, Minkkinen, M, Jørgensen, T, Sondergaard, L, De Backer, O, Engstrøm, T & Lønborg, J 2022, ' Routine revascularization with percutaneous coronary intervention in patients with coronary artery disease undergoing transcatheter aortic valve implantation-the third nordic aortic valve intervention trial-NOTION-3 ', American Heart Journal, vol. 255, pp. 39-51 . https://doi.org/10.1016/j.ahj.2022.10.009 Sabbah, M, Veien, K, Niemela, M, Freeman, P, Linder, R, Ioanes, D, Terkelsen, C J, Kajander, O A, Koul, S, Savontaus, M, Karjalainen, P, Erglis, A, Minkkinen, M, Jørgensen, T, Sondergaard, L, De Backer, O, Engstrøm, T & Lønborg, J 2023, ' Routine revascularization with percutaneous coronary intervention in patients with coronary artery disease undergoing transcatheter aortic valve implantation-the third Nordic Aortic Valve Intervention Trial-NOTION-3 ', American Heart Journal, vol. 255, pp. 39-51 . https://doi.org/10.1016/j.ahj.2022.10.009
DOI:	10.1016/j.ahj.2022.10.009
Popis:	BACKGROUND: Coronary artery disease (CAD) frequently coexists with severe aortic valve stenosis (AS) in patients planned for transcatheter aortic valve implantation (TAVI). How to manage CAD in this patient population is still an unresolved question. In particular, it is still not known whether fractional flow reserve (FFR) guided revascularization with percutaneous coronary intervention (PCI) is superior to medical treatment for CAD in terms of clinical outcomes. STUDY DESIGN: The third Nordic Aortic Valve Intervention (NOTION-3) Trial is an open-label investigator-initiated, multicenter multinational trial planned to randomize 452 patients with severe AS and significant CAD to either FFR-guided PCI or medical treatment, in addition to TAVI. Patients are eligible for the study in the presence of at least 1 significant PCI-eligible coronary stenosis. A significant stenosis is defined as either FFR ≤0.80 and/or diameter stenosis >90%. The primary end point is a composite of first occurring all-cause mortality, myocardial infarction, or urgent revascularization (PCI or coronary artery bypass graft performed during unplanned hospital admission) until the last included patient have been followed for 1 year after the TAVI. SUMMARY: NOTION-3 is a multicenter, multinational randomized trial aiming at comparing FFR-guided revascularization vs medical treatment of CAD in patients with severe AS planned for TAVI. publishedVersion
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f39b4e1fed26739c711665c8a4bb9505 https://pure.au.dk/portal/da/publications/routine-revascularization-with-percutaneous-coronary-intervention-in-patients-with-coronary-artery-disease-undergoing-transcatheter-aortic-valve-implantation--the-third-nordic-aortic-valve-intervention-trial--notion3(8a330048-42b8-4c33-a3b8-a20384f011bd).html Zobrazit plný text záznamu