Laboratory and clinical management of leukocytospermia and hematospermia: a review
| Autor: | Manish Kuchakulla, Aleena Ali, Kajal Khodamoradi, Nancy L. Brackett, Zahra Khosravizadeh, Ranjith Ramasamy, Emad Ibrahim, Manish Narasimman |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.drug_class
030232 urology & nephrology leukocytospermia Semen Review Monoclonal antibody cryopreservation Hematospermia lcsh:Gynecology and obstetrics Cryopreservation Flow cytometry Andrology 03 medical and health sciences 0302 clinical medicine White blood cell medicine lcsh:RG1-991 030219 obstetrics & reproductive medicine medicine.diagnostic_test business.industry lcsh:Public aspects of medicine lcsh:RA1-1270 Sperm sperm separation Red blood cell medicine.anatomical_structure testicular biopsy business hematospermia management |
| Zdroj: | Therapeutic Advances in Reproductive Health Therapeutic Advances in Reproductive Health, Vol 14 (2020) |
| ISSN: | 2633-4941 |
| Popis: | Leukocytospermia and hematospermia are defined as the presence of abnormally high white blood cell and red blood cell concentration in the semen, respectively. Numerous etiologies and various implications on fertility have been identified. In a small proportion of men, the presence of white blood cells or red blood cells can adversely affect sperm quality by the production of reactive oxygen species. Several methods have been used to assess the presence of white blood cells and red blood cells in samples, such as identification of round cells, immunohistochemical staining using monoclonal antibodies, the Endtz test, the peroxidase test, and flow cytometry or microscopy. In addition, techniques have been identified to separate sperm samples from white blood cells and red blood cells for cryopreservation to improve outcomes in assisted reproductive technology. In this review, laboratory and clinical management of leukocytospermia and hematospermia are discussed. Currently available diagnostic methods and treatment options are outlined, and available optimal cryopreservation techniques for samples with white blood cells or red blood cells are summarized. |
| Databáze: | OpenAIRE |
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