Fatty Acid Derivatives Isolated from the Oil of Persea americana (Avocado) Protects against Neomycin-Induced Hair Cell Damage
| Autor: | Tamanna Yasmin, Youn Hee Nam, Seung Hyun Kim, Kwang Won Jeong, Isabel Rodriguez, Jun Hyung Park, Seon Ju Park, Yu Hwa Park, Hee Jae Kwak, Se-Young Choung, Mira Oh, Bin Na Hong, Ji Heon Shim, Do Hoon Kim, Kye Wan Lee, Tong Ho Kang, Jung Suk Lee, Seo Yule Jeong, Youngse Oh, In Seok Moon |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Persea
030309 nutrition & dietetics Hearing loss Plant Science avocado oil Pharmacology fatty acids hair cell Article 03 medical and health sciences 0404 agricultural biotechnology medicine otorhinolaryngologic diseases Avocado Oil Zebrafish Ecology Evolution Behavior and Systematics hearing loss 0303 health sciences Ecology biology Chemistry Botany food and beverages 04 agricultural and veterinary sciences Neomycin medicine.disease biology.organism_classification zebrafish 040401 food science medicine.anatomical_structure QK1-989 Sensorineural hearing loss Hair cell Fatty acid derivatives medicine.symptom medicine.drug |
| Zdroj: | Plants Plants, Vol 10, Iss 171, p 171 (2021) Volume 10 Issue 1 |
| ISSN: | 2223-7747 |
| Popis: | Avocado oil is beneficial to human health and has been reported to have beneficial effects on sensorineural hearing loss (SNHL). However, the compounds in avocado oil that affect SNHL have not been identified. In this study, we identified 20 compounds from avocado oil, including two new and 18 known fatty acid derivatives, using extensive spectroscopic analysis. The efficacy of the isolated compounds for improving SNHL was investigated in an ototoxic zebrafish model. The two new compounds, namely (2R,4R,6Z)-1,2,4-trihydroxynonadec-6-ene and (2R,4R)-1,2,4-trihydroxyheptadecadi-14,16-ene (compounds 1 and 2), as well as compounds 7, 9, 14, 17 and 19 showed significant improvement in damaged hair cells in toxic zebrafish. These results led to the conclusion that compounds from avocado oil as well as oil itself have a regenerative effect on damaged otic hair cells in ototoxic zebrafish. |
| Databáze: | OpenAIRE |
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