Synthesis, spectral characterization, and antituberculosis activity of thiazino[3,2-A]benzimidazole derivatives
| Autor: | Zhen-Lin Cui, Ya He, Yue-Wei Guo, Jing-Xu Gong |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Benzimidazole
010405 organic chemistry Chemistry Organic Chemistry Absolute configuration Crystal structure Mass spectrometry 01 natural sciences Biochemistry Medicinal chemistry 0104 chemical sciences Inorganic Chemistry 010404 medicinal & biomolecular chemistry chemistry.chemical_compound 13c nmr spectroscopy Yield (chemistry) Organic chemistry |
| DOI: | 10.6084/m9.figshare.3444752 |
| Popis: | A series of novel thiazino[3,2-a]benzimidazole derivatives synthesized by cyclization of (R)-2-(chloromethyl)oxirane with benzimidazole-2-thiol followed by reacted with benzyl bromides in high yield under milder conditions. The molecular structures of all compounds were confirmed by 1H and 13C NMR spectroscopy and Mass spectrometry. The absolute configuration of the compounds was confirmed by X-ray diffraction analysis. All the synthesized compounds were evaluated in vitro for their antituberculosis activity. |
| Databáze: | OpenAIRE |
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