Psychopathological Impact in Patients with History of Rheumatic Fever with or without Sydenham's Chorea: A Multicenter Prospective Study
| Autor: | Alessandro Orsini, Thomas Foiadelli, Attilio Sica, Andrea Santangelo, Niccolò Carli, Alice Bonuccelli, Rita Consolini, Sofia D’Elios, Nicolò Loddo, Alberto Verrotti, Giuseppe Di Cara, Chiara Marra, Maria Califano, Anna Fetta, Marianna Fabi, Stefania Bergamoni, Aglaia Vignoli, Roberta Battini, Marta Mosca, Chiara Baldini, Nadia Assanta, Pietro Marchese, Gabriele Simonini, Edoardo Marrani, Francesca Felicia Operto, Grazia Maria Giovanna Pastorino, Salvatore Savasta, Giuseppe Santangelo, Virginia Pedrinelli, Gabriele Massimetti, Liliana Dell’Osso, Diego Peroni, Duccio Maria Cordelli, Martina Corsi, Claudia Carmassi |
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| Přispěvatelé: | Orsini, Alessandro, Foiadelli, Thoma, Sica, Attilio, Santangelo, Andrea, Carli, Niccolò, Bonuccelli, Alice, Consolini, Rita, D'Elios, Sofia, Loddo, Nicolò, Verrotti, Alberto, Di Cara, Giuseppe, Marra, Chiara, Califano, Maria, Fetta, Anna, Fabi, Marianna, Bergamoni, Stefania, Vignoli, Aglaia, Battini, Roberta, Mosca, Marta, Baldini, Chiara, Assanta, Nadia, Marchese, Pietro, Simonini, Gabriele, Marrani, Edoardo, Operto, Francesca Felicia, Pastorino, Grazia Maria Giovanna, Savasta, Salvatore, Santangelo, Giuseppe, Pedrinelli, Virginia, Massimetti, Gabriele, Dell'Osso, Liliana, Peroni, Diego, Cordelli, Duccio Maria, Corsi, Martina, Carmassi, Claudia |
| Rok vydání: | 2022 |
| Předmět: |
Psychopathology
Health Toxicology and Mutagenesis Mental Disorders Public Health Environmental and Occupational Health Sydenham’s chorea acute rheumatic fever neuropsychiatric tests persistent and recurrent chorea Prospective Studie Chorea Mental Disorder Humans neuropsychiatric test Prospective Studies Rheumatic Fever Human |
| Zdroj: | International Journal of Environmental Research and Public Health; Volume 19; Issue 17; Pages: 10586 |
| ISSN: | 1660-4601 |
| Popis: | Sydenham’s chorea (SC) is a post-streptococcal autoimmune disorder of the central nervous system, and it is a major criterium for the diagnosis of acute rheumatic fever (ARF). SC typically improves in 12–15 weeks, but patients can be affected for years by persistence and recurrencies of both neurological and neuropsychiatric symptoms. We enrolled 48 patients with a previous diagnosis of ARF, with or without SC, in a national multicenter prospective study, to evaluate the presence of neuropsychiatric symptoms several years after SC’s onset. Our population was divided in a SC group (n = 21), consisting of patients who had SC, and a nSC group (n = 27), consisting of patients who had ARF without SC. Both groups were evaluated by the administration of 8 different neuropsychiatric tests. The Work and Social Adjustment Scale (WSAS) showed significantly (p = 0.021) higher alterations in the SC group than in the nSC group. Furthermore, 60.4% (n = 29) of the overall population experienced neuropsychiatric symptoms other than choreic movements at diagnosis and this finding was significantly more common (p = 0.00) in SC patients (95.2%) than in nSC patients (33.3%). The other neuropsychiatric tests also produced significant results, indicating that SC can exert a strong psychopathological impact on patients even years after its onset. |
| Databáze: | OpenAIRE |
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