Two new inhibitors of phospholipase A2 produced by Penicillium chermesinum. Taxonomy, fermentation, isolation, structure determination and biological properties
| Autor: | Joseph O'sullivan, Janice H. Johnson, Carol Ann Aklonis, Karen Bush, Pushpa D. Singh, Susan M. Fisher |
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| Rok vydání: | 1985 |
| Předmět: |
Magnetic Resonance Spectroscopy
Chemical Phenomena Naja Metabolite complex mixtures Phospholipases A chemistry.chemical_compound Phospholipase A2 Drug Discovery Crotalus adamanteus Pharmacology biology Penicillium Biological activity biology.organism_classification Chemistry Kinetics Phospholipases A2 Biochemistry chemistry Phospholipases Enzyme inhibitor Fermentation biology.protein lipids (amino acids peptides and proteins) Penicillium chermesinum Naphthoquinones |
| Zdroj: | The Journal of Antibiotics. 38:706-712 |
| ISSN: | 1881-1469 0021-8820 |
| DOI: | 10.7164/antibiotics.38.706 |
| Popis: | Plastatin and the known fungal metabolite, luteosporin, have been isolated from fermentations of Penicillium chermesinum as inhibitors of porcine pancreatic phospholipase A2 (PLA2). Structure 1 for plastatin was deduced from its spectroscopic properties. Plastatin and luteosporin inhibited pancreatic PLA2 competitively with Ki values of 0.89 microM and 12.8 microM, respectively. PLA2 preparations from Naja naja and Crotalus adamanteus were not significantly inhibited by plastatin and luteosporin. |
| Databáze: | OpenAIRE |
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