Predator odor stress blunts alcohol conditioned aversion

Autor: Scott Edwards, Allyson L. Schreiber, M. Adrienne McGinn, Nicholas W. Gilpin
Rok vydání: 2018
Předmět:
0301 basic medicine
Male
medicine.medical_specialty
Alcohol Drinking
Gene Expression
Spatial Behavior
Alcohol
Alcohol use disorder
Amygdala
Article
03 medical and health sciences
Cellular and Molecular Neuroscience
chemistry.chemical_compound
0302 clinical medicine
Extended amygdala
Reward
Internal medicine
Conditioning
Psychological
Avoidance Learning
Medicine
Animals
Rats
Wistar
Cyclic AMP Response Element-Binding Protein
Post-traumatic stress disorder (PTSD)
Pharmacology
Ethanol
business.industry
Traumatic stress
Central Nervous System Depressants
medicine.disease
Olfactory Perception
Protein Tyrosine Phosphatases
Non-Receptor
Housing
Animal
Stria terminalis
030104 developmental biology
Endocrinology
medicine.anatomical_structure
chemistry
Odor
Predatory Behavior
Odorants
Septal Nuclei
business
030217 neurology & neurosurgery
Stress
Psychological
Zdroj: Neuropharmacology. 144
ISSN: 1873-7064
Popis: Alcohol use disorder is highly co-morbid with traumatic stress disorders in humans, and dually diagnosed individuals cite negative affective symptoms as a primary reason for drinking alcohol. Therefore, it is reasonable to hypothesize that traumatic stress history increases the rewarding properties and/or blunts the aversive properties of alcohol. We used a place conditioning procedure to test the rewarding/aversive properties of alcohol in adult male Wistar rats with or without a traumatic stress (i.e., predator odor exposure) history, and with or without an alcohol drinking history. Because extended amygdala regions have documented roles in stress, reward, and stress-induced changes in reward, we also tested the effect of acute alcohol on CREB phosphorylation (pCREB) and striatal-enriched protein tyrosine phosphatase (STEP) expression in central amygdala (CeA) and bed nucleus of stria terminalis (BNST). Our results show that a moderate alcohol dose (1.0 g/kg) produces conditioned place aversion (CPA) that is blunted by stress history but is not affected by alcohol drinking history, and this effect differed in pair-housed versus single-housed rats. Stress history reduced pCREB expression in BNST of rats with and without an alcohol drinking history. Finally, acute alcohol effects on pCREB and STEP expression in CeA were positively associated with preference for the alcohol-paired chamber. These data suggest that stress history reduces the aversive properties of moderate alcohol doses, and that alcohol aversion is associated with acute alcohol effects on pCREB and STEP expression in the extended amygdala.
Databáze: OpenAIRE
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