Cadmium induces impaired glucose tolerance in rat by down-regulating GLUT4 expression in adipocytes

Autor: Byoung G Hah, Jin C Han, Tae H Kwon, Moshen Lachaal, Eui K Kim, Yung K Kim, Chan Y. Jung, Geum H Choi, Wan Lee, Seung Yoon Park
Rok vydání: 2003
Předmět:
Male
medicine.medical_specialty
Time Factors
endocrine system diseases
Monosaccharide Transport Proteins
Biophysics
Down-Regulation
Muscle Proteins
Biochemistry
Diabetes Mellitus
Experimental
Impaired glucose tolerance
Rats
Sprague-Dawley
chemistry.chemical_compound
Downregulation and upregulation
Cadmium Chloride
Adipocyte
Internal medicine
medicine
Adipocytes
Animals
RNA
Messenger
Molecular Biology
Glucose tolerance test
Glucose Transporter Type 1
Glucose Transporter Type 4
medicine.diagnostic_test
biology
Dose-Response Relationship
Drug
Reverse Transcriptase Polymerase Chain Reaction
Muscles
nutritional and metabolic diseases
Glucose Tolerance Test
medicine.disease
Rats
Endocrinology
Glucose
chemistry
Hyperglycemia
biology.protein
GLUT2
3-O-Methylglucose
GLUT1
hormones
hormone substitutes
and hormone antagonists
GLUT4
Cadmium
Zdroj: Archives of biochemistry and biophysics. 413(2)
ISSN: 0003-9861
Popis: Cadmium (Cd) has been known to cause hyperglycemia with diabetes-related complications in experimental animals; however, the molecular basis underlying this Cd-induced hyperglycemia is not known. Here, we report the novel finding that the impaired glucose tolerance (IGT) in rats induced by CdCl(2) is accompanied by a drastic (by as much as 90%) and dose-dependent reduction in GLUT4 protein and GLUT4 mRNA levels in adipocytes. The effect was specific to GLUT4; neither GLUT1 nor insulin-responsive aminopeptidase in adipocytes was affected. GLUT2 in hepatocytes was also not affected. Interestingly, the effect on GLUT4 was also specific to adipocytes; the muscle tissues of the Cd-treated rats showed only a slight (
Databáze: OpenAIRE
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