Multifaceted Effect of Rubus Occidentalis on Hyperglycemia and Hypercholesterolemia in Mice with Diet-Induced Metabolic Diseases
| Autor: | Hye Ran Choi, Jinho An, Jiyeon Kim, Ji-Wung Kwon, Kyungjae Kim, Tae-Bum Lee, Heetae Lee, Hyunseok Kong, Su Jung Lee, Youngcheon Song |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Blood Glucose Male Apolipoprotein B endocrine system diseases Adipose tissue black raspberry 030204 cardiovascular system & hematology cholesterol-lowering effect chemistry.chemical_compound 0302 clinical medicine Black raspberry Hyperlipidemia Medicine diet-induced metabolic diseases model Hypolipidemic Agents Metabolic Syndrome Glucose tolerance test Nutrition and Dietetics medicine.diagnostic_test biology Rubus occidentalis Cholesterol Adipose Tissue Liver anti-diabetic effect lipids (amino acids peptides and proteins) lcsh:Nutrition. Foods and food supply medicine.medical_specialty Lipoproteins Hypercholesterolemia lcsh:TX341-641 Diet High-Fat Article 03 medical and health sciences Internal medicine Animals Hypoglycemic Agents 030109 nutrition & dietetics business.industry Plant Extracts nutritional and metabolic diseases Glucose Tolerance Test medicine.disease biology.organism_classification Lipid Metabolism Mice Inbred C57BL Endocrinology chemistry Hyperglycemia biology.protein Metabolic syndrome business Rubus Food Science Lipoprotein Phytotherapy |
| Zdroj: | Nutrients Volume 10 Issue 12 Nutrients, Vol 10, Iss 12, p 1846 (2018) |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu10121846 |
| Popis: | Metabolic syndrome is characterized by a combination of several metabolic disorders, including obesity, hyperglycemia, and hyperlipidemia. A simultaneous occurrence is one of the most crucial features of metabolic syndrome therefore, we selected an animal model in which this would be reflected. We fed C57BL/6N mice a high-fat diet for 23 weeks to develop metabolic syndrome and examined the efficacy of Rubus occidentalis (RO) for hyperglycemia and hypercholesterolemia. Oral administration of RO for 16 weeks improved hyperglycemia as indicated by significantly decreased fasting glucose levels and a glucose tolerance test. Improvements were also observed in hypercholesterolemia, in which significant decreases in serum total cholesterol, non-high-density lipoprotein (non-HDL) cholesterol, apolipoprotein A-1, and apolipoprotein B levels were observed. The time comparison of major biomarkers, observed at the initiation and termination of the experimental period, consistently supported the beneficial effects of RO on each metabolic phenotype. In addition, RO treatment attenuated the excessive fat accumulation in hepatic and adipose tissue by decreasing the size and number of lipid droplets. These results suggested that RO simultaneously exerted antihyperglycemic and antihyperlipidemic effects in mice with diet-induced metabolic syndrome. |
| Databáze: | OpenAIRE |
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