Extracellular vesicles in vascular calcification
| Autor: | Wei Yan, Yangfeng Hou, Bu Zou, Shun-Lin Qu, Wenling Yang, Tao Chen |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Cell signaling Pathology medicine.medical_specialty Clinical Biochemistry Cell Biochemistry Extracellular vesicles Muscle Smooth Vascular Pathogenesis Extracellular Vesicles 03 medical and health sciences 0302 clinical medicine medicine Humans Vascular Calcification Vascular calcification business.industry Biochemistry (medical) General Medicine medicine.disease Microvesicles 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis business Intracellular Calcification |
| Zdroj: | Clinica Chimica Acta. 499:118-122 |
| ISSN: | 0009-8981 |
| DOI: | 10.1016/j.cca.2019.09.002 |
| Popis: | Vascular calcification is associated with adverse cardiovascular events that increase the risk of cardiovascular death. Unfortunately, the pathogenesis of vascular calcification is complex and incompletely understood. As important intercellular signaling molecules, the role of extracellular vesicles (EVs) in vascular calcification has attracted wide attention in recent years. This review will briefly describe the role of EVs (mainly including exosomes and microvesicles) in the process of vascular wall calcification focusing on the specific mechanisms of smooth muscle cell (SMC) differentiation and calcium-phosphorus balance to illustrate the relationship between EVs and vascular calcification. It is likely that EVs may be prognostic markers in some cardiovascular diseases and have potential therapeutic potential. |
| Databáze: | OpenAIRE |
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