Tetrapetalone A, a novel lipoxygenase inhibitor from Streptomyces sp
| Autor: | Naoki Abe, Misako Imachi, Hiroshi Hirota, Yasumasa Sugiyama, Akira Hirota, Toshikazu Komoda |
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| Rok vydání: | 2003 |
| Předmět: |
biology
Strain (chemistry) Chemistry Diazomethane Stereochemistry Chemical structure Organic Chemistry General Medicine biology.organism_classification Biochemistry Streptomyces Lipoxygenase chemistry.chemical_compound Drug Discovery Proton NMR biology.protein Moiety Two-dimensional nuclear magnetic resonance spectroscopy |
| Zdroj: | Tetrahedron Letters. 44:1659-1661 |
| ISSN: | 0040-4039 |
| DOI: | 10.1016/s0040-4039(03)00007-8 |
| Popis: | Tetrapetalone A ( I ), C26H33O7N, is a novel lipoxygenase inhibitor isolated from a culture filtrate of Streptomyces sp. USF-4727 strain. Its chemical structure was determined by its spectroscopic evidence and methylation with diazomethane. The stereochemistry was investigated by the coupling constant in 1H NMR, NOESY data and modified Mosher's method. I possessed a tetracyclic skeleton and a β-rhodinosyl moiety, and this is the first report of a compound with such a tetracyclic skeleton. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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