The role of platelets in inflammatory immune responses in generalized aggressive periodontitis
Autor: | Huanxin Meng, Jianxia Hou, Xian'e Wang, Ruifang Lu, Xiaojun Sun, Yalin Zhan |
---|---|
Rok vydání: | 2017 |
Předmět: |
Adult
Blood Platelets Male 0301 basic medicine Endothelium Inflammation 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Immune system medicine Humans Aggressive periodontitis Platelet Longitudinal Studies Mean platelet volume Cell Size business.industry Large cell medicine.disease 030104 developmental biology medicine.anatomical_structure Aggressive Periodontitis Immunology Periodontics Immunohistochemistry Female medicine.symptom business |
Zdroj: | Journal of Clinical Periodontology. 44:150-157 |
ISSN: | 0303-6979 |
Popis: | Aim To investigate the relationship between inflammatory markers and platelet size in generalized aggressive periodontitis (GAgP). Material and Methods Periodontal, inflammatory, and platelet indices were compared between 59 GAgP patients and 59 healthy subjects. Gingival biopsies from 5 patients and 5 healthy subjects were examined by immunohistochemistry and electron microscopy. Changes in patient periodontal and platelet indices were re-evaluated at 3 months after periodontal therapy. Results Platelet size was decreased significantly in GAgP patients compared to healthy subjects (p ≤ 0.003). Weak negative correlations between platelet size and periodontal parameters were found in GAgP patients (p ≤ 0.025). Platelet aggregates and adhesion to the endothelium or leukocytes were found in venules and connective tissues of gingival biopsies from GAgP patients. Mean platelet volume (MPV) and platelet large cell ratio (PLCR) increased after periodontal therapy in GAgP patients (p ≤ 0.038). The increase in MPV was related to the decrease in bleeding index (BI) in GAgP patients after periodontal therapy (p < 0.001; r = 0.357). Conclusion Platelet size was reduced in GAgP patients compared to healthy controls, possibly due to the consumption of large platelets at sites of periodontal inflammation. Platelets may be involved in host responses to periodontal infection in GAgP. This article is protected by copyright. All rights reserved. |
Databáze: | OpenAIRE |
Externí odkaz: |