Serotypes and clonal composition of streptococcus pneumoniae isolates causing IPD in children and adults in Catalonia before 2013 to 2015 and after 2017 to 2019 systematic introduction of PCV13
| Autor: | Redin, A., Ciruela, P., De Sevilla, M. F., Gomez-Bertomeu, F., Gonzalez-Peris, S., Benitez, M. A., Trujillo, G., Diaz, A., Jou, E., Izquierdo, C., Perez-Moreno, M. O., Moraga-Llop, F., Olsina, M., Vinado, B., Sanfeliu, E., Garcia, A., Gonzalez-di Lauro, S., Garcia-Garcia, J. J., Dominguez, A., Sa-Leao, R., Muñoz Almagro, Carmen, Catalan Study Group of Invasive Pneumococcal DiseaseSHOW FEWER |
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| Přispěvatelé: | Institut Català de la Salut, [Redin A] Institut de Recerca Sant Joan de Deu, Hospital Sant Joan de Deu, Barcelona, Spain. Departament de Medicina, Universitat Internacional de Catalunya, Barcelona, Spain. [Ciruela P] CIBER de Epidemiologia y Salud Publica (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain. Agencia de Salut Publica de Catalunya (ASPCAT), Generalitat de Catalunya, Barcelona, Spain. [de Sevilla MF] Institut de Recerca Sant Joan de Deu, Hospital Sant Joan de Deu, Barcelona, Spain. CIBER de Epidemiologia y Salud Publica (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain. [Gomez-Bertomeu F] Hospital Universitari Joan XXIII, Tarragona, Spain. [Gonzalez-Peris S, Moraga-Llop F, Vinado B] Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Benitez MA] Hospital comarcal Alt Penedes, Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Systematic vaccination Physiology Serotypes Infeccions per pneumococs Bacteria::Bacteria::Gram-Positive Bacteria::Gram-Positive Cocci::Streptococcaceae::Streptococcus::Bacteria::Gram-Positive Bacteria::Streptococcus pneumoniae [ORGANISMS] Pneumococcal Vaccines invasive pneumococcal disease clones Vacunació Child Vacunació presistemàtica Vacunación presistemática Vacunes antibacterianes Streptococcus pneumoniae Aged 80 and over Ecology Pneumococs pneumococcal conjugate vaccines Polysaccharides Bacterial Vaccination Complex Mixtures::Biological Products::Vaccines::Bacterial Vaccines::Streptococcal Vaccines::Pneumococcal Vaccines [CHEMICALS AND DRUGS] Invasive pneumococcal disease Middle Aged QR1-502 humanities Infectious Diseases Malaltia pneumocòcica invasiva Presystematic vaccination Child Preschool Female Research Article Adult Microbiology (medical) Enfermedad neumocócica invasiva serotypes Adolescent infecciones bacterianas y micosis::infecciones bacterianas::infecciones por bacterias grampositivas::infecciones estreptocócicas::infecciones neumocócicas [ENFERMEDADES] Serogroup Microbiology Pneumococcal Infections Young Adult Serotips Genetics Humans Vacunació sistemàtica Aged mezclas complejas::productos biológicos::vacunas::vacunas bacterianas::vacunas antiestreptocócicas::vacunas antineumocócicas [COMPUESTOS QUÍMICOS Y DROGAS] Bacterial Infections and Mycoses::Bacterial Infections::Gram-Positive Bacterial Infections::Streptococcal Infections::Pneumococcal Infections [DISEASES] General Immunology and Microbiology Infant Newborn Vacunación Infant Pneumococcal vaccine Cell Biology bacterial infections and mycoses Vacuna antipneumocòccica Infeccions per estreptococs Spain Vacunación sistemática Serotipos Bacteria::Bacteria::bacterias grampositivas::cocos grampositivos::Streptococcaceae::Streptococcus::Bacteria::bacterias grampositivas::Streptococcus pneumoniae [ORGANISMOS] |
| Zdroj: | Microbiology spectrum r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu instname Microbiology Spectrum Scientia Microbiology Spectrum, Vol 9, Iss 3 (2021) Dipòsit Digital de la UB Universidad de Barcelona |
| ISSN: | 2165-0497 |
| Popis: | Clones; Invasive pneumococcal disease; Serotypes Clones; Enfermedad neumocócica invasiva; Serotipos Clons; Malaltia pneumocòcica invasiva; Serotips The goal of this study was to investigate the distribution of serotypes and clonal composition of Streptococcus pneumoniae isolates causing invasive pneumococcal disease (IPD) in Catalonia, before and after systematic introduction of PCV13. Pneumococcal strains isolated from normally sterile sites obtained from patients of all ages with IPD received between 2013 and 2019 from 25 health centers of Catalonia were included. Two study periods were defined: presystematic vaccination period (2013 and 2015) and systematic vaccination period (SVP) (2017 to 2019). A total of 2,303 isolates were analyzed. In the SVP, there was a significant decrease in the incidence of IPD cases in children 5 to 17 years old (relative risk [RR] 0.61; 95% confidence interval [CI] 0.38 to 0.99), while there was a significant increase in the incidence of IPD cases in 18- to 64-year-old adults (RR 1.33; 95% CI 1.16 to 1.52) and adults over 65 years old (RR 1.23; 95% CI 1.09 to 1.38). Serotype 8 was the major emerging serotype in all age groups except in 5- to 17-year-old children. In children younger than 5 years old, the main serotypes in SVP were 24F, 15A, and 3, while in adults older than 65 years they were serotypes 3, 8, and 12F. A significant decrease in the proportions of clonal complexes CC156, CC191, and ST306 and an increase in those of CC180, CC53, and CC404 were observed. A steady decrease in the incidence of IPD caused by PCV13 serotypes indicates the importance and impact of systematic vaccination. The increase of non-PCV13 serotypes highlights the need to expand serotype coverage in future vaccines and rethink vaccination programs for older adults. IMPORTANCE We found that with the incorporation of the PCV13 vaccine, the numbers of IPD cases caused by serotypes included in this vaccine decreased in all of the age groups. Still, there was an unforeseen increase of the serotypes not included in this vaccine causing IPD, especially in the >65-year-old group. Moreover, a significant increase of serotype 3 included in the vaccine has been observed; this event has been reported by other researchers. These facts call for the incorporation of more serotypes in future vaccines and a more thorough surveillance of the dynamics of this microorganism. |
| Databáze: | OpenAIRE |
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