Chronic exposure to imidacloprid or thiamethoxam neonicotinoid causes oxidative damages and alters carotenoid-retinoid levels in caged honey bees (Apis mellifera)
Autor: | Maxime Gauthier, Monique Boily, Philippe Aras, Joanne Paquin |
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Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Vitamin Male Insecticides alpha-Tocopherol lcsh:Medicine 010501 environmental sciences Biology 01 natural sciences Article Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound Neonicotinoids Pollinator Imidacloprid Animals Food science Toxicity Tests Chronic lcsh:Science Carotenoid Cryptoxanthins 0105 earth and related environmental sciences chemistry.chemical_classification Multidisciplinary fungi lcsh:R Neonicotinoid food and beverages Pesticide Bees Nitro Compounds Carotenoids Biosynthetic Pathways Oxidative Stress 030104 developmental biology chemistry behavior and behavior mechanisms Insect Proteins Female lcsh:Q Lipid Peroxidation Thiamethoxam Biomarkers |
Zdroj: | Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018) Scientific Reports |
ISSN: | 2045-2322 |
Popis: | Over the last decade, the persistent dwindling of the populations of honey bees has become a growing concern. While this phenomenon is partly attributed to neonicotinoids (NEOCs), chronic exposures to these insecticides at environmentally-relevant concentrations are needed to fully estimate their implications. In this study, honey bees were orally exposed for 10 days to low field-realistic concentrations of NEOCs known for their effects on the cholinergic system (imidacloprid – IMI or thiamethoxam – THM). Selected biomarkers were measured such as acetylcholinesterase (AChE) activity, lipid peroxidation (LPO), α-tocopherol as well as several forms of vitamin A (retinoids) and carotenoids. Bees exposed to IMI showed lower levels of two carotenoids (α-carotene and α-cryptoxanthin) and α-tocopherol. The THM exposure increased the oxidized vitamin A metabolites in bees conjointly with the LPO. These results could be the consequence of a pro-oxidant effect of NEOCs and were observed at levels where no effects were recorded for AChE activity. This study reveals that exposure to low levels of NEOCs alters the carotenoid-retinoid system in honey bees. This would merit further investigation as these compounds are important in various aspects of bees’ health. Overall, this study contributes to the development of biomonitoring tools for the health of bees and other pollinators. |
Databáze: | OpenAIRE |
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